Halliwell B, Aruoma O I, Mufti G, Bomford A
Department of Biochemistry, Medical School, King's College, University of London, England.
FEBS Lett. 1988 Dec 5;241(1-2):202-4. doi: 10.1016/0014-5793(88)81061-5.
Patients with acute myeloid leukaemia show elevated plasma iron and, in 2/6 cases studied, low-molecular-mass iron complexes capable of stimulating radical reactions were present in the plasma. Shortly after the onset of chemotherapy, there is a sharp rise in transferrin saturation and all patients studied showed low-molecular-mass iron in their plasma. It is proposed that such iron could interact with oxidants generated by certain drugs (e.g. adriamycin or daunorubicin) to facilitate tissue damage, and that some of the side-effects of chemotherapy might be ameliorated by careful co-administration of small doses of desferrioxamine.
急性髓系白血病患者血浆铁水平升高，在所研究的6例中有2例，血浆中存在能够刺激自由基反应的低分子量铁复合物。化疗开始后不久，转铁蛋白饱和度急剧上升，所有研究患者的血浆中均显示有低分子量铁。有人提出，这种铁可能与某些药物（如阿霉素或柔红霉素）产生的氧化剂相互作用，从而促进组织损伤，并且谨慎地联合小剂量去铁胺给药可能会改善化疗的一些副作用。
