细胞毒性化疗后的非转铁蛋白结合铁与中性粒细胞减少症
Non-transferrin bound iron and neutropenia after cytotoxic chemotherapy.
作者信息
Harrison P, Marwah S S, Hughes R T, Bareford D
机构信息
Department of Haematology, Dudley Road Hospital, Birmingham.
出版信息
J Clin Pathol. 1994 Apr;47(4):350-2. doi: 10.1136/jcp.47.4.350.
AIMS
To investigate and characterise the appearance of non-transferrin bound iron (NTBI) in the serum of patients after cytotoxic chemotherapy and to compare this with the onset and duration of neutropenia.
METHOD
Non-transferrin bound iron was measured by a bleomycin assay in patients undergoing intensive chemotherapy for treatment of acute leukaemia or lymphoma.
RESULTS
NTBI was detected after 26 of 27 courses of chemotherapy and lasted for a mean of 14.5 days. The presence of NTBI correlated with the serum iron binding saturation, but not with serum ferritin. Neutropenia occurred after all courses of chemotherapy and lasted for a mean of 20.0 days. NTBI and neutropenia occurred concurrently after 23 courses of chemotherapy, and had a mean joint duration of 9.5 days.
CONCLUSIONS
NTBI is consistently present in the serum of patients after cytotoxic chemotherapy, often at the same time as the patient is neutropenic. This may be an additional risk factor for the development of infective episodes after chemotherapy.
目的
研究并描述细胞毒性化疗后患者血清中非转铁蛋白结合铁（NTBI）的表现，并将其与中性粒细胞减少症的发生及持续时间进行比较。
方法
采用博来霉素检测法对接受强化化疗治疗急性白血病或淋巴瘤的患者进行非转铁蛋白结合铁检测。
结果
27个化疗疗程中有26个检测到NTBI，其平均持续时间为14.5天。NTBI的存在与血清铁结合饱和度相关，但与血清铁蛋白无关。所有化疗疗程后均出现中性粒细胞减少症，平均持续时间为20.0天。23个化疗疗程后NTBI和中性粒细胞减少症同时出现，平均共同持续时间为9.5天。
结论
细胞毒性化疗后患者血清中始终存在NTBI，通常与患者中性粒细胞减少症同时出现。这可能是化疗后发生感染性疾病的一个额外危险因素。
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