Fukunaga Keisuke, Hatanaka Takaaki, Ito Yuji, Minami Michiko, Taki Masumi
Department of Engineering Science, Bioscience and Technology Program, The Graduate School of Informatics and Engineering, The University of Electro-Communications (UEC), 1-5-1 Chofugaoka, Chofu, Tokyo 182-8585, Japan.
Chem Commun (Camb). 2014 Apr 18;50(30):3921-3. doi: 10.1039/c4cc00811a. Epub 2014 Mar 11.
By using the 10BASEd-T, we have synthesized a crown ether-like macrocyclic library possessing randomized peptide linkers on bacteriophage T7. Among 1.5 × 10(9) diversities of the supramolecule candidates, we have obtained a specific binder for the N-terminal domain of Hsp90.
通过使用10BASEd-T，我们在噬菌体T7上合成了一个具有随机肽接头的类冠醚大环文库。在1.5×10⁹种超分子候选物的多样性中，我们获得了一种针对Hsp90 N端结构域的特异性结合剂。
