From the Division of Chinese Trauma, China Medical University Hospital, China Medical University, Taichung, Department of Diagnostic Radiology, Chang Gung Memorial Hospital, Chiayi and Chang Gung University, Tao Yuan, Molecular and Genomic Epidemiology Center, China Medical University Hospital, China Medical University, Taichung, Management Office for Health Data, China Medical University Hospital, Taichung; Department of Public Health, China Medical University, Taichung, Kau-Tang Traditional Medical Hospital, TaoYuan and Department of Nuclear Medicine and PET Center, China Medical University Hospital and Graduate Institute of Clinical Medicine Science and School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.
From the Division of Chinese Trauma, China Medical University Hospital, China Medical University, Taichung, Department of Diagnostic Radiology, Chang Gung Memorial Hospital, Chiayi and Chang Gung University, Tao Yuan, Molecular and Genomic Epidemiology Center, China Medical University Hospital, China Medical University, Taichung, Management Office for Health Data, China Medical University Hospital, Taichung; Department of Public Health, China Medical University, Taichung, Kau-Tang Traditional Medical Hospital, TaoYuan and Department of Nuclear Medicine and PET Center, China Medical University Hospital and Graduate Institute of Clinical Medicine Science and School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan
QJM. 2014 Aug;107(8):635-41. doi: 10.1093/qjmed/hcu037. Epub 2014 Mar 11.
Chronic fatigue syndrome (CFS) is a complex disorder that is associated with unreasonable persistent fatigue. CFS has also been reported to be a possible risk factor for osteopathy. We propose that CFS might be associated with an increased risk of fracture.
We used the National Health Insurance Research Database to conduct a prospective cohort study, identifying 3744 patients with a CFS diagnosis (International Classification of Diseases, Ninth Revision, Clinical Modification code 780.71) and 14 976 patients without CFS until 2006, with follow-up observed until the end of 2010.
The incidence rate of fracture was higher in the CFS cohort than in the non-CFS cohort (17.44 vs. 14.53 per 1000 person-year, respectively), with an adjusted hazard ratio of 1.14 (95% confidence interval = 1.00-1.30). The risks of fracture between CFS and non-CFS were shown without comorbidity for each would be elevated than with other comorbidities, particularly in osteoporosis. The patients without osteoporosis in the CFS cohort exhibited a 1.16-fold higher risk of fracture than did those in the non-CFS cohort.
We propose that CFS-related fracture might not be associated with osteoporosis. The mechanism for developing CFS-related fracture remains unclear; however, we recommend noticing the prevention of fracture for CFS patients before clarifying the aetiology of CFS-related fracture.
慢性疲劳综合征（CFS）是一种复杂的疾病，其特征是不合理的持续疲劳。也有报道称，CFS 可能是骨病的一个潜在危险因素。我们提出，CFS 可能与骨折风险增加有关。
我们使用国家健康保险研究数据库进行了一项前瞻性队列研究，确定了 3744 例 CFS 诊断患者（国际疾病分类，第九版，临床修正码 780.71）和 14976 例非 CFS 患者，随访至 2006 年，观察至 2010 年底。
CFS 队列的骨折发生率高于非 CFS 队列（分别为 17.44 比 14.53/1000 人年），调整后的危险比为 1.14（95%置信区间为 1.00-1.30）。在没有合并症的情况下，CFS 和非 CFS 之间的骨折风险均显示出升高，而合并症越多，风险越高，特别是骨质疏松症。在 CFS 队列中没有骨质疏松症的患者骨折风险比非 CFS 队列高 1.16 倍。
我们提出，CFS 相关骨折可能与骨质疏松症无关。CFS 相关骨折发生的机制尚不清楚；然而，我们建议在明确 CFS 相关骨折的病因之前，注意预防 CFS 患者发生骨折。
