Xi Bo, Zhao Xiaoyuan, Shen Yue, Wu Lijun, Hou Dongqing, Cheng Hong, Mi Jie
Department of Maternal and Child Health Care, School of Public Health, Shandong University, Jinan, 250012, China.
Endocrine. 2014 Dec;47(3):825-32. doi: 10.1007/s12020-014-0217-y. Epub 2014 Mar 12.
A great number of body mass index (BMI)/obesity-related loci have been identified by recent genome-wide association studies. The objective of the study is to investigate the associations of 11 obesity-related loci with insulin resistance (IR) in a Chinese children population. Participants included 3,468 Chinese children, aged 6-18 years. The 75 percentile (equal to 2.93) of homeostasis model assessment of IR (HOMA-IR) index was considered as the cut-off of IR. A total of 868 IR cases and 2,600 control children were identified. In age- and sex-adjusted model, only two SNPs in/near GNPDA2 and KCTD15 genes were significantly associated with risk of IR [GNPDA2 rs10938397: allelic odds ratio (OR) = 1.19, 95 % confidence interval (CI) 1.06-1.34, P = 0.003; KCTD15 rs29941: allelic OR = 1.15, 95 % CI = 1.01-1.31, P = 0.034]; genetic risk score was also significantly associated risk of IR (OR = 1.08, 95 % 1.04-1.12, P = 1.18 × 10(-4)). After additional adjustment for BMI, none remained significant. The associations of GNPDA2 rs10938397 and the SNPs in combination with risk of IR remained statistically significant after correction for multiple testing. The present study demonstrated that the associations of GNPDA2 rs10938397 and the SNPs in combination with risk of IR were statistically significant, which were dependent on BMI.
近期的全基因组关联研究已鉴定出大量与体重指数（BMI）/肥胖相关的基因座。本研究的目的是在中国儿童群体中调查11个肥胖相关基因座与胰岛素抵抗（IR）之间的关联。研究对象包括3468名6至18岁的中国儿童。IR的稳态模型评估（HOMA-IR）指数的第75百分位数（等于2.93）被视为IR的临界值。共识别出868例IR病例和2600名对照儿童。在年龄和性别调整模型中，仅GNPDA2和KCTD15基因内/附近的两个单核苷酸多态性（SNP）与IR风险显著相关[GNPDA2 rs10938397：等位基因优势比（OR）=1.19，95%置信区间（CI）1.06 - 1.34，P = 0.003；KCTD15 rs29941：等位基因OR = 1.15，95% CI = 1.01 - 1.
