Department of Gastric Cancer and Soft Tissue Sarcoma, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
J Surg Oncol. 2014 Jun;109(8):859-64. doi: 10.1002/jso.23599. Epub 2014 Mar 12.
The aim of this study was to evaluate the expression of CD24, p21, p53, and c-myc in lesions of patients with Alpha-Fetoprotein (AFP)-producing gastric cancer and their correlation with clinicopathological features and prognosis.
One hundred and four patients with AFP-producing gastric cancer were included into this study. The levels of CD24, p21, p53, and c-myc were examined by immunohistochemistry.The prognostic value of these biological markers and the correlation between biological markers and clinicopathological factors were investigated.
The percentages of positive expression of CD24, p21, p53, and c-myc were 31.7%, 77.9%, 75.0%, and 66.3%, respectively. CD24 expression correlated with histological grade (P = 0.045) and Lauren type (P = 0.006); p21expression with Borrmann type (P = 0.035); c-myc expression with Borrmann type (P = 0.029). p21 expression was related with poor survival in univariate analysis (P = 0.016). Multivariate analysis showed that p21 expression, vascular invasion, and pathological stage were defined as independent prognostic factors.
The expression of p21 was an independent prognostic factor for patients with AFP-producing gastric cancer.
本研究旨在评估甲胎蛋白（AFP）产生型胃癌患者病变中 CD24、p21、p53 和 c-myc 的表达及其与临床病理特征和预后的关系。
本研究纳入了 104 例 AFP 产生型胃癌患者。采用免疫组织化学法检测 CD24、p21、p53 和 c-myc 的表达水平。探讨这些生物标志物的预后价值及其与临床病理因素的相关性。
CD24、p21、p53 和 c-myc 的阳性表达率分别为 31.7%、77.9%、75.0%和 66.3%。CD24 表达与组织学分级（P=0.045）和 Lauren 分型（P=0.006）相关；p21 表达与 Borrmann 分型（P=0.035）相关；c-myc 表达与 Borrmann 分型（P=0.029）相关。单因素分析显示，p21 表达与不良生存相关（P=0.016）。多因素分析显示，p21 表达、血管侵犯和病理分期是独立的预后因素。
p21 的表达是 AFP 产生型胃癌患者的独立预后因素。
