墨西哥裔美国人胆碱的膳食摄入量与神经管缺陷

Dietary intake of choline and neural tube defects in Mexican Americans.

作者信息

Lavery Amy M, Brender Jean D, Zhao Hongwei, Sweeney Anne, Felkner Marilyn, Suarez Lucina, Canfield Mark A

机构信息

College of Health Professions and Social Work, Temple University, Philadelphia, Pennsylvania; Department of Epidemiology & Biostatistics, Texas A&M Health Science Center, School of Rural Public Health, College Station, Texas.

出版信息

Birth Defects Res A Clin Mol Teratol. 2014 Jun;100(6):463-71. doi: 10.1002/bdra.23236. Epub 2014 Mar 12.

DOI:10.1002/bdra.23236

PMID:24619903

Abstract

BACKGROUND

Low maternal intake of dietary choline and betaine (a choline derivative) has recently been investigated as a possible risk factor for neural tube defects (NTDs).

METHODS

This case-control study examined the NTD risk associated with choline and betaine in 409 Mexican-American women who gave birth during 1995 to 2000 in the 14-county border region of Texas.

RESULTS

Using data from the food frequency questionnaire and the lowest quartiles of intake as the reference categories, a protective association was suggested between higher intakes of choline and betaine and NTD risk although the 95% confidence intervals for all risk estimates included 1.0. For choline intake in the second, third, and fourth quartiles, adjusted odds ratios were 1.2, 0.80, and 0.89, respectively. Betaine appeared more protective with odds ratios of 0.62, 0.73, and 0.61, respectively, for the second, third, and fourth quartiles of intake.

CONCLUSION

Study findings suggest that dietary betaine may help to prevent NTDs.

摘要

背景

孕妇膳食中胆碱和甜菜碱（一种胆碱衍生物）摄入量低最近被作为神经管缺陷（NTDs）的一个可能风险因素进行了研究。

方法

这项病例对照研究调查了1995年至2000年期间在得克萨斯州14县边境地区分娩的409名墨西哥裔美国妇女中与胆碱和甜菜碱相关的NTD风险。

结果

以食物频率问卷数据和摄入量的最低四分位数作为参考类别，尽管所有风险估计值的95%置信区间都包含1.0，但较高的胆碱和甜菜碱摄入量与NTD风险之间存在保护性关联。对于胆碱摄入量处于第二、第三和第四四分位数的情况，调整后的优势比分别为1.2、0.80和0.89。甜菜碱的保护作用似乎更强，摄入量处于第二、第三和第四四分位数时，优势比分别为0.62、0.73和0.61。