Butchiram M S, Kumar M Vijaya, Tilak K S
J Environ Biol. 2013 Mar;34(2):247-51.
Histopathological changes in vital tissues like gills, liver and kidney in the fish Labeo rohita exposed for 8 days to sublethal (5.2 mgl(-1)) and lethal concentration (25.09 mg(-1)) of phenol were studied. The observed histopathological changes in the gills were epithelial hyperplasia with lamellar fusion, epithelial hypertrophy, edema, general necrosis, increased mucous production and degeneration of primary and secondary gill lamellae at sublethal (5.2 mg l(-1)) and degenerated primary and secondary gill lamellae, lamellar fusion and lamellar disorganization at lethal (25.09 mg l(-1)) concentration. In the liver, the changes include as: formation of number of vacuoles, enlargement of nuclei of some cells, enlarged sinusoids with numerous blood cells and atrophic areas at sublethal (5.2 mg I(-1)) concentration and nuclear and cytoplasmic degeneration and melanomacrophages aggregates at lethal (25.09 mg I(-1)) concentration. In case of kidney, the changes were: degeneration of proximal and distal convoluted tubule, vacuolation of renal interstitial tissue and deformation of the nuclear membrane of some cells at sublethal (5.2 mg l(-1)) and occlusion of tubular lumen, cloudy swelling degeneration and hyaline droplets degeneration at lethal (25.09 mg l(-1)) concentration.
研究了暴露于亚致死浓度（5.2毫克/升）和致死浓度（25.09毫克/升）苯酚8天的露斯塔野鲮鱼鳃、肝脏和肾脏等重要组织的组织病理学变化。在亚致死浓度（5.2毫克/升）下，观察到鳃的组织病理学变化为上皮增生伴片状融合、上皮肥大、水肿、普遍坏死、黏液分泌增加以及初级和次级鳃小片退化；在致死浓度（25.09毫克/升）下，初级和次级鳃小片退化、片状融合和片状紊乱。在肝脏中，亚致死浓度（5.2毫克/升）下的变化包括：形成多个液泡、一些细胞核增大、血窦扩大且有大量血细胞以及出现萎缩区域；在致死浓度（25.09毫克/升）下，出现细胞核和细胞质退化以及黑色素巨噬细胞聚集。在肾脏中，亚致死浓度（5.2毫克/升）下的变化为：近端和远端曲管退化、肾间质组织空泡化以及一些细胞核膜变形；在致死浓度（25.09毫克/升）下，出现肾小管腔阻塞、混浊肿胀变性和透明滴状变性。
