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成人活体肝移植后门静脉血栓形成的雷克斯分流术

Rex shunt for portal vein thrombosis after adult living donor liver transplantation.

作者信息

Soejima Yuji, Shirabe Ken, Yoshizumi Tomoharu, Uchiyama Hideaki, Ikegami Toru, Yamashita Yo-Ichi, Ikeda Tetsuo, Kawanaka Hirofumi, Sugimachi Keishi, Mimori Koshi, Watanabe Masayuki, Morita Masaru, Oki Eiji, Saeki Hiroshi, Maehara Yoshihiko

出版信息

Fukuoka Igaku Zasshi. 2013 Nov;104(11):464-8.

Abstract

Portal vein thrombosis (PVT) after liver transplantation is a relatively common but serious complication which could lead to portal hypertension or a direct graft loss. A "Rex" shunt created between the superior mesenteric vein (SMV) and the umbilical portion of the left portal vein can be a useful option to treat PVT after pediatric liver transplantation, however, its application to adult patients has not been reported so far because appropriate vein grafts are hardly available. Herein we present a case of PVT after left lobe living donor liver transplantation (LDLT) who underwent the procedure using the own inferior jugular vein and the gonadal vein as a shunt graft. The shunt was patent immediately after the procedure but was thrombosed 2 days after probably due to the insufficient inflow from the SMV and the absence of anticoagulation therapy, for which emergent thrombectomy and ligation of the significant hepatofugal collateral veins followed by full anti-coagulation therapy were performed. The shunt remains open at 8 month after the procedure with a normal anmonia level and liver function. In conclusion, the Rex shunt using recipient's autologous vein grafts is a feasible and valuable option for adult patients to treat PVT after LDLT.

摘要

肝移植后门静脉血栓形成(PVT)是一种相对常见但严重的并发症,可导致门静脉高压或直接导致移植肝失功。在肠系膜上静脉(SMV)和左门静脉脐部之间建立的“雷克斯”分流术可作为小儿肝移植后治疗PVT的一种有效选择,然而,由于难以获得合适的静脉移植物,其在成人患者中的应用迄今尚未见报道。在此,我们报告一例左半肝活体供肝肝移植(LDLT)后发生PVT的病例,该患者接受了使用自身颈内静脉和性腺静脉作为分流移植物的手术。分流术后即刻通畅,但术后2天发生血栓形成,可能是由于来自SMV的血流不足以及未进行抗凝治疗,为此进行了急诊血栓切除术并结扎了重要的肝外分流侧支静脉,随后进行了充分的抗凝治疗。术后8个月分流保持通畅,氨水平和肝功能正常。总之,使用受者自体静脉移植物的雷克斯分流术是治疗成人LDLT后PVT的一种可行且有价值的选择。

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