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小儿活体肝移植后门静脉血栓形成行 ReX 分流术。

Rex Shunt for Portal Vein Thrombosis After Pediatric Living Donor Liver Transplantation.

机构信息

Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka City, Fukuoka, Japan.

Department of Pediatric Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka City, Fukuoka, Japan.

出版信息

Ann Transplant. 2021 Dec 15;26:e909493. doi: 10.12659/AOT.909493.

Abstract

BACKGROUND Portal vein thrombosis (PVT) after pediatric liver transplantation (LT) is a common but grave complication which could eventually result in life-threatening portal hypertension. A "Rex" shunt between the superior mesenteric vein and the Rex recess of the liver has been reported to be a treatment option for extrahepatic portal vein obstruction; however, its application to living donor liver transplantation (LDLT) is limited due to the availability of appropriate vein grafts. In this study, we retrospectively evaluated the effectiveness of Rex shunt as an option for the treatment of PVT after pediatric LDLT. CASE REPORT Three children underwent the Rex shunt for early (n=2) and late (n=1) PVT after LDLT using the greater saphenous vein (n=2) and the external iliac vein (n=1) from the parents who previously donated their livers. Two of the 3 children are free from symptoms with patent shunt grafts at 14 years after the procedures. One child died at 30 days after LDLT due to repeated episodes of PVT, which finally led to hepatic infarction. CONCLUSIONS The Rex shunt is feasible to treat PVT after LDLT. However, additional surgical insults to the living donor need further discussion.

摘要

背景

小儿肝移植(LT)后门静脉血栓形成(PVT)是一种常见但严重的并发症,最终可导致危及生命的门静脉高压。肠系膜上静脉与肝的 Rex 隐窝之间的“Rex”分流术已被报道可作为治疗肝外门静脉阻塞的一种选择;然而,由于合适静脉移植物的可用性,其在活体肝移植(LDLT)中的应用受到限制。在本研究中,我们回顾性评估了 Rex 分流术作为治疗小儿 LDLT 后 PVT 的一种选择的有效性。

病例报告

3 名儿童在 LDLT 后因早期(n=2)和晚期(n=1)PVT 而行 Rex 分流术,使用来自先前捐献肝脏的父母的大隐静脉(n=2)和髂外静脉(n=1)。3 名儿童中有 2 名在手术后 14 年没有症状,分流移植通畅。1 名儿童在 LDLT 后 30 天因反复发生 PVT 最终导致肝梗死而死亡。

结论

Rex 分流术可用于治疗 LDLT 后 PVT。然而,对活体供体的额外手术创伤需要进一步讨论。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9fb/8690054/ea7e8a87eb24/anntransplant-26-e909493-g001.jpg

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