Duchesne G, Cassoni A, Pera M
Institute of Cancer Research, Sutton, Surrey, U.K.
Radiother Oncol. 1988 Oct;13(2):153-61. doi: 10.1016/0167-8140(88)90036-9.
A panel of human lung carcinoma lines was studied with respect to hormone production and intermediate filament expression to distinguish between endodermal and neuroendocrine differentiation. An index of the degree of neuroendocrine differentiation of each line was derived from the presence or absence of hormone production, cytokeratins, neurofilaments and an embryonic endodermal cell marker, which allowed identification of three groups showing high, intermediate or low neuroendocrine expression. This grouping correlated well with the in vitro radiosensitivity of the lines, those expressing pure neuroendocrine features being significantly more radiosensitive than those with an endodermal phenotype, with the intermediate group having intermediate sensitivity. Use of such an index might predict those patients likely to benefit from the use of radiotherapy in their management.
对一组人肺癌细胞系进行了激素产生和中间丝表达方面的研究，以区分内胚层分化和神经内分泌分化。根据激素产生、细胞角蛋白、神经丝和一种胚胎内胚层细胞标志物的有无，得出每条细胞系神经内分泌分化程度的指标，据此可将其分为三组，分别显示高、中或低神经内分泌表达。这种分组与细胞系的体外放射敏感性密切相关，表现出纯神经内分泌特征的细胞系比具有内胚层表型的细胞系对放疗敏感得多，中间组的敏感性则处于中间水平。使用这样一个指标可能有助于预测哪些患者在治疗中可能从放疗中获益。
