Yao Gen-You, Zhou Ji-Lin, Lai Mao-De, Chen Xiao-Qing, Chen Pei-Hui
Research fellow of Pathology, Department of Pathology, Zhejiang University Medical School, Hangzhou, 310031 China.
World J Gastroenterol. 2003 Apr;9(4):858-61. doi: 10.3748/wjg.v9.i4.858.
To investigate the incidence of neuroendocrine (NE) cells and their hormone products in adenocarcinomas and evaluate their significance in clinical pathology and prognosis.
By using tissue sectioning and immunocyto-chemistry, 356 cases of adenocarcinomas were studied to examine the presence of chromorgranin and polypeptide hormones in adenocarcinoma samples from our hospital.
The positive rate of NE cells and hormone products was 41.5 % (54/130) and 59.3 % (32/54), respectively in large intestinal adenocarcinoma cases; 39.6 % (38/96) and 36.8 % (14/38), respectively in gastric cancer cases; 38.1 % (8/21) and 50.0 % (4/8), respectively in prostatic cancer cases; 21.0 % (17/81) and 17.6 % (3/17), respectively in breasr cancer cases; 17.9 % (5/28) and 60.0 % (3/5), respectively in pancreatic cancer cases. Among carcinomas of large intestine, pancreas and breast, the highly differentiated NE cell numbers were higher than the poorly differentiated NE cell numbers; while the gastric carcinoma cases had more poorly differentiated NE cells than highly differentiated NE cells. The higher detection rate of NE cells and their hormone products, the higher 5-year survival rate among the large intestine cancer cases.
Close correlation was observed between NE cells and their hormone products with the cancer differentiations. For colorectal carcinomas, there is a close correlation of the presence of NE cells and their hormone products with the tumor staging and prognosis.
研究神经内分泌（NE）细胞及其激素产物在腺癌中的发生率，并评估其在临床病理及预后中的意义。
采用组织切片及免疫细胞化学方法，对我院356例腺癌样本进行研究，检测嗜铬粒蛋白和多肽激素的存在情况。
在大肠腺癌病例中，NE细胞和激素产物的阳性率分别为41.5%（54/130）和59.3%（32/54）；在胃癌病例中分别为39.6%（38/96）和36.8%（14/38）；在前列腺癌病例中分别为38.1%（8/21）和50.0%（4/8）；在乳腺癌病例中分别为21.0%（17/81）和17.6%（3/17）；在胰腺癌病例中分别为17.9%（5/28）和60.0%（3/5）。在大肠、胰腺和乳腺癌中，高分化NE细胞数量多于低分化NE细胞数量；而胃癌病例中低分化NE细胞多于高分化NE细胞。在大肠癌病例中，NE细胞及其激素产物的检测率越高，5年生存率越高。
观察到NE细胞及其激素产物与癌症分化之间密切相关。对于结直肠癌，NE细胞及其激素产物的存在与肿瘤分期及预后密切相关。
