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本文引用的文献

1
Expression of somatostatin receptor and effects of somatostatin analog on pancreatic endocrine tumors.生长抑素受体的表达及生长抑素类似物对胰腺内分泌肿瘤的影响。
Surg Today. 2002;32(8):690-4. doi: 10.1007/s005950200128.
2
Studies on the DNA content of breast carcinoma cells with neuroendocrine differentiation.
Chin Med J (Engl). 2002 Feb;115(2):296-8.
3
Evaluation of chromogranin A expression in serum and tissues of breast cancer patients.乳腺癌患者血清和组织中嗜铬粒蛋白A表达的评估。
Int J Biol Markers. 2001 Oct-Dec;16(4):268-72. doi: 10.1177/172460080101600408.
4
Classification of gastric neuroendocrine tumors and its clinicopathologic significance.胃神经内分泌肿瘤的分类及其临床病理意义。
World J Gastroenterol. 1998 Apr;4(2):158-161. doi: 10.3748/wjg.v4.i2.158.
5
Epidemiology, clinical features and diagnosis of gastroenteropancreatic endocrine tumours.胃肠胰内分泌肿瘤的流行病学、临床特征与诊断
Ann Oncol. 2001;12 Suppl 2:S95-9. doi: 10.1093/annonc/12.suppl_2.s95.
6
Clinical significance of neuroendocrine carcinoma of the breast.乳腺神经内分泌癌的临床意义
Ann Oncol. 2001;12 Suppl 2:S115-7. doi: 10.1093/annonc/12.suppl_2.s115.
7
Chromogranin A in human neuroendocrine tumors: an immunohistochemical study with region-specific antibodies.人神经内分泌肿瘤中的嗜铬粒蛋白A：一项使用区域特异性抗体的免疫组织化学研究
Am J Surg Pathol. 2001 Oct;25(10):1261-7. doi: 10.1097/00000478-200110000-00006.
8
Neuroendocrine differentiation is a relevant prognostic factor in stage III-IV colorectal cancer.神经内分泌分化是Ⅲ-Ⅳ期结直肠癌的一个相关预后因素。
Eur J Gastroenterol Hepatol. 2001 Apr;13(4):405-11. doi: 10.1097/00042737-200104000-00018.
9
A new human chromogranin 'A' immunoradiometric assay for the diagnosis of neuroendocrine tumours.一种用于诊断神经内分泌肿瘤的新型人嗜铬粒蛋白“A”免疫放射分析方法。
Br J Cancer. 2001 Mar 2;84(5):636-42. doi: 10.1054/bjoc.2000.1659.
10
Neuroendocrine-like differentiation in patients with pancreatic carcinoma.胰腺癌患者的神经内分泌样分化
Cancer. 2000 Dec 1;89(11):2230-6. doi: 10.1002/1097-0142(20001201)89:11<2230::aid-cncr11>3.0.co;2-x.

腺癌中的神经内分泌标志物：356例病例的研究

Neuroendocrine markers in adenocarcinomas: an investigation of 356 cases.

作者信息

Yao Gen-You, Zhou Ji-Lin, Lai Mao-De, Chen Xiao-Qing, Chen Pei-Hui

机构信息

Research fellow of Pathology, Department of Pathology, Zhejiang University Medical School, Hangzhou, 310031 China.

出版信息

World J Gastroenterol. 2003 Apr;9(4):858-61. doi: 10.3748/wjg.v9.i4.858.

DOI:10.3748/wjg.v9.i4.858
PMID:12679948
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4611465/
Abstract

AIM

To investigate the incidence of neuroendocrine (NE) cells and their hormone products in adenocarcinomas and evaluate their significance in clinical pathology and prognosis.

METHODS

By using tissue sectioning and immunocyto-chemistry, 356 cases of adenocarcinomas were studied to examine the presence of chromorgranin and polypeptide hormones in adenocarcinoma samples from our hospital.

RESULTS

The positive rate of NE cells and hormone products was 41.5 % (54/130) and 59.3 % (32/54), respectively in large intestinal adenocarcinoma cases; 39.6 % (38/96) and 36.8 % (14/38), respectively in gastric cancer cases; 38.1 % (8/21) and 50.0 % (4/8), respectively in prostatic cancer cases; 21.0 % (17/81) and 17.6 % (3/17), respectively in breasr cancer cases; 17.9 % (5/28) and 60.0 % (3/5), respectively in pancreatic cancer cases. Among carcinomas of large intestine, pancreas and breast, the highly differentiated NE cell numbers were higher than the poorly differentiated NE cell numbers; while the gastric carcinoma cases had more poorly differentiated NE cells than highly differentiated NE cells. The higher detection rate of NE cells and their hormone products, the higher 5-year survival rate among the large intestine cancer cases.

CONCLUSION

Close correlation was observed between NE cells and their hormone products with the cancer differentiations. For colorectal carcinomas, there is a close correlation of the presence of NE cells and their hormone products with the tumor staging and prognosis.

摘要

目的

研究神经内分泌（NE）细胞及其激素产物在腺癌中的发生率，并评估其在临床病理及预后中的意义。

方法

采用组织切片及免疫细胞化学方法，对我院356例腺癌样本进行研究，检测嗜铬粒蛋白和多肽激素的存在情况。

结果

在大肠腺癌病例中，NE细胞和激素产物的阳性率分别为41.5%（54/130）和59.3%（32/54）；在胃癌病例中分别为39.6%（38/96）和36.8%（14/38）；在前列腺癌病例中分别为38.1%（8/21）和50.0%（4/8）；在乳腺癌病例中分别为21.0%（17/81）和17.6%（3/17）；在胰腺癌病例中分别为17.9%（5/28）和60.0%（3/5）。在大肠、胰腺和乳腺癌中，高分化NE细胞数量多于低分化NE细胞数量；而胃癌病例中低分化NE细胞多于高分化NE细胞。在大肠癌病例中，NE细胞及其激素产物的检测率越高，5年生存率越高。

结论

观察到NE细胞及其激素产物与癌症分化之间密切相关。对于结直肠癌，NE细胞及其激素产物的存在与肿瘤分期及预后密切相关。