钯(0)催化的活化烯烃的自由基芳基二氟甲基化反应。
Pd(0)-Catalyzed radical aryldifluoromethylation of activated alkenes.
机构信息
Department of Chemistry, University of Technology of China, Hefei 230026, China.
出版信息
Chem Commun (Camb). 2014 Apr 21;50(31):4108-11. doi: 10.1039/c3cc49315f.
PMID:24622897
Abstract
A Pd(0)-catalyzed intramolecular aryldifluoromethylation of activated alkenes under mild reaction conditions has been developed. This reaction provides a new method for construction of a variety of difluoromethylated oxindoles. Mechanistic investigations indicate that a difluoromethyl radical, which was triggered by Pd(0), initiated the cascade sequence through an addition to the alkene.
摘要
发展了一种在温和反应条件下钯(0)催化的活化烯烃的分子内芳基二氟甲基化反应。该反应为构建各种二氟甲基化氧化吲哚提供了一种新方法。机理研究表明，Pd(0)引发的二氟甲基自由基通过与烯烃加成引发了级联反应。
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