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卵巢促纤维增生性小圆细胞肿瘤:一种在年轻女性中罕见但极具破坏性的疾病。

Desmoplastic small round cell tumor of the ovary: A rare but devastating disease in young women.

作者信息

Nakayama John, Nassau Sarah, Atkins Kristen, Modesitt Susan C

机构信息

University of Virginia Medical Center, Division of Gynecologic Oncology, Dept. of OB/GYN, PO Box 800712 Charlottesville, VA 22908, USA.

University of Virginia Medical Center, Dept. of Pathology, PO Box 800904 Charlottesville, VA 22908, USA.

出版信息

Gynecol Oncol Case Rep. 2013 Feb 26;7:16-8. doi: 10.1016/j.gynor.2013.02.006. eCollection 2014 Jan.

DOI:10.1016/j.gynor.2013.02.006
PMID:24624323
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3895282/
Abstract

•Desmoplastic small round cell tumor of the ovary is a rare clinical entity with poor prognosis.•Accurate diagnosis utilizes a combination of histological, immunohistological, and cytogenetic findings.•This disease should be kept on the differential diagnosis in young women with widespread disease on presentation.

摘要

•卵巢促纤维增生性小圆细胞肿瘤是一种临床罕见且预后不良的实体瘤。

•准确诊断需结合组织学、免疫组织学及细胞遗传学检查结果。

•对于初诊时患有广泛病变的年轻女性,应将此病列入鉴别诊断范围。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f39d/3895282/fd20a6547c32/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f39d/3895282/a71b04993326/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f39d/3895282/fd20a6547c32/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f39d/3895282/a71b04993326/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f39d/3895282/fd20a6547c32/gr2.jpg

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2
Ovarian involvement by desmoplastic small round cell tumor with leydig cell hyperplasia showing an unusual immunophenotype (cytokeratin negative, calretinin and inhibin positive) mimicking poorly differentiated sertoli leydig cell tumor.卵巢硬纤维瘤伴有间质细胞瘤样增生,表现出一种不常见的免疫表型(细胞角蛋白阴性,钙视网膜蛋白和抑制素阳性),类似于低分化支持细胞间质细胞瘤。
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