Oncology (Williston Park). 2013 Dec;27(12):1263-9, 1274-9.
Advances in next-generation sequencing technologies in recent years have allowed in-depth study of somatic mutations in over 1,000 breast cancer samples.The Cancer Genome Atlas (TCGA) is the largest single genome-characterization effort to date. It is remarkable for the integration of DNA sequencing with genome-wide profiling of the epigenome, microRNAome, transcriptome, and proteome for more than 500 diverse primary untreated breast cancers. This article aims to provide an overview ofTCGA findings, with a particular focus on their potential biological relevance and therapeutic implications.
近年来，下一代测序技术的进步使得对超过 1000 个乳腺癌样本中的体细胞突变进行深入研究成为可能。癌症基因组图谱（TCGA）是迄今为止最大的单一基因组特征分析工作。它的显著特点是将 DNA 测序与对超过 500 个不同的未经治疗的原发性乳腺癌的全基因组表观基因组、microRNAome、转录组和蛋白质组进行整合。本文旨在概述 TCGA 的发现，特别关注其潜在的生物学相关性和治疗意义。
