Negi H, Sarkar M, Raval A D, Pandey K, Das P
Department of Pharmacy Practice, National Institute of Pharmaceutical Education and Research, Hajipur, India.
J Postgrad Med. 2014 Jan-Mar;60(1):7-11. doi: 10.4103/0022-3859.128797.
Chronic obstructive pulmonary disease (COPD) is a major health problem in India and constitutes an important cause of mortality and morbidity. A cross-sectional study was undertaken to assess health-related quality of life (HRQL) and its determinants in patients with COPD from India.
A total of 126 patients (73.81% male) were enrolled using convenient sampling prospectively in this cross-sectional study. Eligible patients were assessed for socioeconomic status, anthropometric measures, COPD severity, dyspnea and health status using the Hindi version of St George's Respiratory Questionnaire (SGRQ). Linear regression model was used to examine the association between risk factors and HRQL score (a higher score indicating poorer HRQL), adjusting for age and sex.
The mean total score for SGRQ in the patients was 52.66 ± 12.89, indicating a marked impairment of HRQL. Impairment was associated with the severity of airway obstruction, but within each Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage, the variation (SD) was wide [stage I: 47.8 ± 12.3 (n = 14); stage II: 49.28 ± 11.69 (n = 47); stage III: 53.47 ± 11.69 (n = 44); stage IV: 61.75 ± 14.14 (n = 21)]. A regression analysis showed that body mass index, forced expiratory volume in 1 s (FEV 1 ), dyspnea grade, and depression were associated with poor HRQL.
HRQL of COPD patients was significantly impaired across stages. Marked impairment of HRQL was found even in patients with mild disease.
慢性阻塞性肺疾病（COPD）是印度的一个主要健康问题，是导致死亡和发病的重要原因。本研究开展了一项横断面研究，以评估印度COPD患者的健康相关生活质量（HRQL）及其决定因素。
本横断面研究采用方便抽样法前瞻性纳入了126例患者（男性占73.81%）。使用印地语版的圣乔治呼吸问卷（SGRQ）对符合条件的患者进行社会经济状况、人体测量指标、COPD严重程度、呼吸困难和健康状况评估。采用线性回归模型检验危险因素与HRQL评分（分数越高表明HRQL越差）之间的关联，并对年龄和性别进行校正。
患者的SGRQ平均总分是52.66±12.89，表明HRQL显著受损。这种损害与气道阻塞的严重程度相关，但在慢性阻塞性肺疾病全球倡议（GOLD）的每个阶段内，差异（标准差）都很大[I期：47.8±12.3（n = 14）；II期：49.28±11.69（n = 47）；III期：53.47±11.69（n = 44）；IV期：61.75±14.14（n = 21）]。回归分析表明，体重指数、第1秒用力呼气容积（FEV1）、呼吸困难分级和抑郁与较差的HRQL相关。
COPD患者各阶段的HRQL均显著受损。即使是轻度疾病患者也存在HRQL的显著损害。
