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脑膜炎奈瑟菌作为面部蜂窝织炎的病因

Neisseria meningitidis as a cause of facial cellulitis.

作者信息

Ozaki Brent, Kittai Adam, Chang Suzanne

机构信息

The George Washington University, Washington, DC, USA.

出版信息

BMJ Case Rep. 2014 Mar 13;2014:bcr2014203774. doi: 10.1136/bcr-2014-203774.

DOI:10.1136/bcr-2014-203774
PMID:24626385
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3962945/
Abstract

A 68-year-old man presented with facial cellulitis and found to have Neisseria meningitidis bacteraemia with no evidence of infection outside of the facial soft tissue. He was treated with a course of intravenous ceftriaxone and transitioned to oral amoxicillin on discharge with significant improvement of his symptoms. N meningitidis is best recognised as a causal agent of bacterial meningitis. To our knowledge N meningitidis cellulitis has only been described in 12 other cases. In this case series we describe and summarise our case, along with the 12 cases already reported in the literature. We report this case series to highlight the importance of recognising N meningitidis in the differential in patients presenting with acute skin and soft tissue infections especially involving the periorbital, head and neck regions.

摘要

一名68岁男性因面部蜂窝织炎就诊,被发现患有脑膜炎奈瑟菌血症,面部软组织以外无感染迹象。他接受了一个疗程的静脉注射头孢曲松治疗,并在出院时改用口服阿莫西林,症状有明显改善。脑膜炎奈瑟菌最广为人知的是细菌性脑膜炎的病原体。据我们所知,脑膜炎奈瑟菌蜂窝织炎仅在其他12例病例中被描述过。在本病例系列中,我们描述并总结了我们的病例以及文献中已报道的12例病例。我们报告这个病例系列是为了强调在鉴别诊断急性皮肤和软组织感染(尤其是累及眶周、头部和颈部区域)的患者时识别脑膜炎奈瑟菌的重要性。

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本文引用的文献

1
First reported case of Neisseria meningitidis periorbital cellulitis associated with meningitis.首例与脑膜炎相关的脑膜炎奈瑟菌眶周蜂窝织炎病例报告。
Pediatrics. 2005 Dec;116(6):e874-5. doi: 10.1542/peds.2005-0694.
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Clinical practice. Cellulitis.临床实践。蜂窝织炎。
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Fatal acute cellulitis due to Neisseria meningitidis.由脑膜炎奈瑟菌引起的致命性急性蜂窝织炎。
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Meningococcal cellulitis and sialadenitis.
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Meningococcal endocarditis presenting as cellulitis.表现为蜂窝织炎的脑膜炎球菌性心内膜炎。
Clin Infect Dis. 1995 Oct;21(4):1023-5. doi: 10.1093/clinids/21.4.1023.
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Variation in phenotypic expression of the Opa outer membrane protein and lipooligosaccharide of Neisseria meningitidis serogroup C causing periorbital cellulitis and bacteremia.引起眶周蜂窝织炎和菌血症的C群脑膜炎奈瑟菌Opa外膜蛋白和脂寡糖表型表达的变异
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Neisseria meningitidis cellulitis.
South Med J. 1972 Oct;65(10):1243-4. doi: 10.1097/00007611-197210000-00015.
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Skin manifestations of meningococcal infection; an immediate indicator of prognosis.脑膜炎球菌感染的皮肤表现:预后的直接指标。
Am J Dis Child. 1974 Feb;127(2):173-6. doi: 10.1001/archpedi.1974.02110210023003.