胃旁路手术后致获得性补体缺陷相关坏死性蜂窝织炎的脑膜炎球菌血症：一例报告。
Meningococcaemia causing necrotizing cellulitis associated with acquired complement deficiency after gastric bypass surgery: a case report.
机构信息
Department of Intensive Care, Erasme Hospital, Université Libre de Bruxelles, 808 Route de Lennik, Brussels, Belgium.
Department of Infectious Diseases, Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium.
出版信息
BMC Infect Dis. 2020 May 20;20(1):361. doi: 10.1186/s12879-020-05079-3.
BACKGROUND
Neisseria meningitidis has rarely been described as an agent of necrotic soft tissue infection.
CASE PRESENTATION
We report a case of a septic shock with necrotizing cellulitis due to Neisseria meningitidis serogroup W, treated by urgent extensive surgical debridement followed by skin grafts. The invasive meningococcal disease occurred together with a complement deficiency, possibly acquired after bypass surgery that took place 1 year before.
CONCLUSIONS
Necrotic tissue infections should be considered part of the invasive meningococcal diseases spectrum and should prompt clinicians to look for complement deficiencies. Gastric bypass surgery associated malnutrition may be implicated but further verification is needed.
背景
脑膜炎奈瑟菌很少被描述为导致坏死性软组织感染的病原体。
病例介绍
我们报告了一例由 W 群脑膜炎奈瑟菌引起的感染性休克合并坏死性蜂窝织炎的病例，该患者接受了紧急广泛的外科清创术和植皮治疗。侵袭性脑膜炎球菌病与补体缺乏症同时发生，这种补体缺乏症可能是在 1 年前旁路手术后获得的。
结论
坏死组织感染应被视为侵袭性脑膜炎球菌病谱的一部分，并促使临床医生寻找补体缺乏症。与胃旁路手术相关的营养不良可能与此有关，但需要进一步证实。
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