van de Bor M, Verloove-Vanhorick S P, Baerts W, Brand R, Ruys J H
Department of Pediatrics, University Hospital Leiden, The Netherlands.
Neuropediatrics. 1988 Nov;19(4):183-5. doi: 10.1055/s-2008-1052442.
Of 484 newborn infants with a gestational age of less than 32 weeks and admitted to 6 neonatal intensive care units in the Netherlands, 294 survived and were available for follow-up at the corrected age of two years. The total incidence of impaired neurodevelopmental outcome was 23.1%. Sixty-nine children had a periventricular-intraventricular hemorrhage (PIVH) in the neonatal period: 31 grade I, 21 grade II, 12 grade III, 5 grade IV. Children with grade I and II PIVH had significantly more handicaps than children without PIVH (36.5% vs 17.8%, p less than 0.01). This held even true after the data were adjusted for possible confounding factors (odds ratio [OR] 2.1, confidence interval [1.3, 3.3], p less than 0.01). Children with grade III and IV PIVH had also more handicaps than children without PIVH (52.9% vs 17.8%, p less than 0.001); after adjustment for confounding factors the OR was 3.0, confidence interval [1.6, 5.5], p less than 0.01. The difference between children with grade I and II PIVH and children with grade III and IV PIVH was not significant.
在荷兰6家新生儿重症监护病房收治的484例孕周小于32周的新生儿中，294例存活并在矫正年龄两岁时接受随访。神经发育结局受损的总发生率为23.1%。69名儿童在新生儿期发生了脑室周围-脑室内出血（PIVH）：31例为I级，21例为II级，12例为III级，5例为IV级。I级和II级PIVH患儿的残障情况显著多于无PIVH的患儿（36.5%对17.8%，p<0.01）。即使在对可能的混杂因素进行数据调整后也是如此（优势比[OR]2.1，置信区间[1.3, 3.3]，p<0.01）。III级和IV级PIVH患儿的残障情况也多于无PIVH的患儿（52.9%对17.8%，p<0.001）；在对混杂因素进行调整后，OR为3.0，置信区间[1.6, 5.5]，p<0.01。I级和II级PIVH患儿与III级和IV级PIVH患儿之间的差异不显著。
