接受髓母细胞瘤治疗儿童的工作记忆能力：家长报告与儿童表现
Working memory abilities among children treated for medulloblastoma: parent report and child performance.
作者信息
Knight Sarah J, Conklin Heather M, Palmer Shawna L, Schreiber Jane E, Armstrong Carol L, Wallace Dana, Bonner Melanie, Swain Michelle A, Evankovich Karen D, Mabbott Donald J, Boyle Robyn, Huang Qinlei, Zhang Hui, Anderson Vicki A, Gajjar Amar
机构信息
Clinical Sciences, Murdoch Childrens Research Institute, Children's Cancer Centre and Psychology Department, Royal Children's Hospital, Victorian Paediatric Rehabilitation Service, Monash Children's, Department of Paediatrics, The University of Melbourne, Department of Psychology, St. Jude Children's Research Hospital, Neuro-Oncology Program, Children's Hospital of Philadelphia, Department of Psychiatry, Duke University Medical Center, Royal Children's Hospital, Department of Pediatric Medicine, Texas Children's Hospital, Department of Psychology, The Hospital for Sick Children, Psychology Service, Sydney Children's Hospital, Department of Biostatistics St. Jude Children's Research Hospital, and Department of Oncology, St. Jude Children's Research HospitalClinical Sciences, Murdoch Childrens Research Institute, Children's Cancer Centre and Psychology Department, Royal Children's Hospital, Victorian Paediatric Rehabilitation Service, Monash Children's, Department of Paediatrics, The University of Melbourne, Department of Psychology, St. Jude Children's Research Hospital, Neuro-Oncology Program, Children's Hospital of Philadelphia, Department of Psychiatry, Duke University Medical Center, Royal Children's Hospital, Department of Pediatric Medicine, Texas Children's Hospital, Department of Psychology, The Hospital for Sick Children, Psychology Service, Sydney Children's Hospital, Department of Biostatistics St. Jude Children's Research Hospital, and Department of Oncology, St. Jude Children's Research HospitalClinical Sciences, Murdoch Childrens Research Institute, Children's Cancer Centre and Psychology Department, Royal Children's Hospital, Victorian Paediatric Rehabilitation Service, Monash Children's, Department of Paediatrics, The University of Melbourne, Department of Psychology, St. Jude Children's Research Hospital, Neuro-Oncology Program, Children's Hospital of Philadelphia, Department of Psychiatry, Duke University Medical Center, Royal Children's Hospital, D
Clinical Sciences, Murdoch Childrens Research Institute, Children's Cancer Centre and Psychology Department, Royal Children's Hospital, Victorian Paediatric Rehabilitation Service, Monash Children's, Department of Paediatrics, The University of Melbourne, Department of Psychology, St. Jude Children's Research Hospital, Neuro-Oncology Program, Children's Hospital of Philadelphia, Department of Psychiatry, Duke University Medical Center, Royal Children's Hospital, Department of Pediatric Medicine, Texas Children's Hospital, Department of Psychology, The Hospital for Sick Children, Psychology Service, Sydney Children's Hospital, Department of Biostatistics St. Jude Children's Research Hospital, and Department of Oncology, St. Jude Children's Research Hospital.
出版信息
J Pediatr Psychol. 2014 Jun;39(5):501-11. doi: 10.1093/jpepsy/jsu009. Epub 2014 Mar 12.
OBJECTIVE
We investigated the 5-year postsurgical developmental trajectory of working memory (WM) in children with medulloblastoma using parent and performance-based measures.
METHOD
This study included 167 patients treated for medulloblastoma. Serial assessments of WM occurred at predetermined time points for 5 years.
RESULTS
There was a subtle, statistically significant increase in parental concern about WM, coupled with a statistically significant decrease in age-standardized scores on performance-based measures. However, whole-group mean scores on both parent and performance-based measures remained in the age-expected range. Posterior fossa syndrome was consistently associated with poorer WM. Younger age at treatment and higher treatment intensity were associated with greater negative change in WM performance only.
CONCLUSIONS
Most children treated for medulloblastoma display WM within the age-appropriate range according to parent report and performance. However, the subtle negative changes over time and identified subgroups at increased risk highlight the need for ongoing monitoring of this population.
目的
我们使用家长报告和基于表现的测量方法，研究了髓母细胞瘤患儿术后5年工作记忆（WM）的发育轨迹。
方法
本研究纳入了167例接受髓母细胞瘤治疗的患者。在预定的时间点对WM进行了连续5年的评估。
结果
家长对WM的担忧有细微的、具有统计学意义的增加，同时基于表现的测量中年龄标准化分数有具有统计学意义的下降。然而，家长报告和基于表现的测量的全组平均分数仍处于年龄预期范围内。后颅窝综合征一直与较差的WM相关。治疗时年龄较小和治疗强度较高仅与WM表现的更大负向变化相关。
结论
根据家长报告和表现，大多数接受髓母细胞瘤治疗的儿童的WM处于适合年龄的范围内。然而，随着时间的细微负向变化以及确定的高风险亚组凸显了对该人群进行持续监测的必要性。
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