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Functional MRI in medulloblastoma survivors supports prophylactic reading intervention during tumor treatment.髓母细胞瘤幸存者的功能磁共振成像支持在肿瘤治疗期间进行预防性阅读干预。
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本文引用的文献

1
How parents cope with their child's diagnosis and treatment of an embryonal tumor: results of a prospective and longitudinal study.家长如何应对孩子胚胎性肿瘤的诊断和治疗:一项前瞻性和纵向研究的结果。
J Neurooncol. 2011 Nov;105(2):253-9. doi: 10.1007/s11060-011-0574-9. Epub 2011 Apr 19.
2
A pilot study of an online cognitive rehabilitation program for executive function skills in children with cancer-related brain injury.一项针对癌症相关脑损伤儿童执行功能技能的在线认知康复计划的试点研究。
Brain Inj. 2011;25(1):101-12. doi: 10.3109/02699052.2010.536194.
3
Computerized cognitive training in survivors of childhood cancer: a pilot study.儿童癌症幸存者的计算机化认知训练:一项试点研究。
J Pediatr Oncol Nurs. 2011 Jan-Feb;28(1):27-33. doi: 10.1177/1043454210377178. Epub 2010 Oct 21.
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Neurodevelopmental impact on children treated for medulloblastoma: a review and proposed conceptual model.髓母细胞瘤治疗对儿童神经发育的影响:综述与概念模型建议
Dev Disabil Res Rev. 2008;14(3):203-10. doi: 10.1002/ddrr.32.
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Core neurocognitive functions in children treated for posterior fossa tumors.后颅窝肿瘤治疗儿童的核心神经认知功能。
Neuropsychology. 2008 Mar;22(2):159-68. doi: 10.1037/0894-4105.22.2.159.
6
Understanding the cognitive impact on children who are treated for medulloblastoma.了解髓母细胞瘤治疗对儿童认知功能的影响。
J Pediatr Psychol. 2007 Oct;32(9):1040-9. doi: 10.1093/jpepsy/jsl056. Epub 2007 Feb 28.
7
Neurocognitive effects of treatment for childhood cancer.儿童癌症治疗的神经认知影响。
Ment Retard Dev Disabil Res Rev. 2006;12(3):184-91. doi: 10.1002/mrdd.20110.
8
Early patterns of verbal memory impairment in children treated for medulloblastoma.接受髓母细胞瘤治疗的儿童早期言语记忆障碍模式。
Neuropsychology. 2006 Jan;20(1):105-12. doi: 10.1037/0894-4105.20.1.105.
9
Neurocognitive consequences of risk-adapted therapy for childhood medulloblastoma.儿童髓母细胞瘤风险适应性治疗的神经认知后果
J Clin Oncol. 2005 Aug 20;23(24):5511-9. doi: 10.1200/JCO.2005.00.703.
10
Neurocognitive late effects in pediatric cancer.儿童癌症的神经认知晚期效应
Curr Probl Cancer. 2003 Jul-Aug;27(4):177-97. doi: 10.1016/s0147-0272(03)00026-6.

一项旨在预防正在接受髓母细胞瘤积极治疗的儿童出现阅读解码缺陷的计算机辅助干预措施的可行性和效果:一项随机试验的结果

Feasibility and efficacy of a computer-based intervention aimed at preventing reading decoding deficits among children undergoing active treatment for medulloblastoma: results of a randomized trial.

作者信息

Palmer Shawna L, Leigh Laurie, Ellison Susan C, Onar-Thomas Arzu, Wu Shengjie, Qaddoumi Ibrahim, Armstrong Gregory T, Wright Karen, Wetmore Cynthia, Broniscer Alberto, Gajjar Amar

机构信息

Department of Psychology, St. Jude Children's Research Hospital, Mail Stop 740, 262 Danny Thomas Place, Memphis, TN 38105, USA.

出版信息

J Pediatr Psychol. 2014 May;39(4):450-8. doi: 10.1093/jpepsy/jst095. Epub 2013 Dec 25.

DOI:10.1093/jpepsy/jst095
PMID:24369366
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3994317/
Abstract

OBJECTIVE

To investigate the feasibility of a computer-based reading intervention completed by patients diagnosed with a brain tumor.

METHODS

Patients were randomized to the intervention (n = 43) or standard of care group (n = 38). The intervention consisted of 30 sessions using Fast ForWord® exercises in a game-like format. Change in reading decoding scores over time since diagnosis was examined. Gender, race, parent education, parent marital status, and age at diagnosis were examined as covariates.

RESULTS

17 patients (39.5%) were able to complete the target goal of 30 intervention sessions. Females had significantly greater training time than males (p = .022). Age at diagnosis was associated with average training time/session for females (r = .485, p = .041). No significant differences were found in reading scores between the randomized groups.

CONCLUSIONS

The study was well accepted by families and adherence by patients undergoing radiation therapy for medulloblastoma was moderate. Suggestions for improved methodology are discussed.

摘要

目的

探讨脑肿瘤患者完成基于计算机的阅读干预的可行性。

方法

将患者随机分为干预组(n = 43)或标准治疗组(n = 38)。干预包括以游戏形式进行30节使用Fast ForWord®练习的课程。检查自诊断以来阅读解码分数随时间的变化。将性别、种族、父母教育程度、父母婚姻状况和诊断时的年龄作为协变量进行检查。

结果

17名患者(39.5%)能够完成30节干预课程的目标。女性的训练时间明显长于男性(p = 0.022)。诊断时的年龄与女性的平均每次训练时间相关(r = 0.485,p = 0.041)。随机分组之间的阅读分数没有显著差异。

结论

该研究受到家庭的广泛接受,接受髓母细胞瘤放射治疗的患者的依从性中等。讨论了改进方法的建议。