THE OHIO STATE UNIVERSITY.
Blood. 2014 Mar 6;123(10):1438. doi: 10.1182/blood-2014-01-548578.
In this issue of Blood, Ito et al demonstrate pathogenic implications of microRNA-150 (miR-150) repression in an aggressive form of cutaneous T-cell lymphoma (CTCL). Noncoding RNAs, such as microRNA, profoundly influence gene transcription and protein translation machinery to change hematopoietic cell fate in physiologic and pathologic conditions.
在本期《Blood》中，Ito 等人证明了 microRNA-150（miR-150）抑制在侵袭性皮肤 T 细胞淋巴瘤（CTCL）中的致病意义。非编码 RNA，如 microRNA，深刻地影响基因转录和蛋白质翻译机制，以改变生理和病理条件下造血细胞的命运。
