Yu Xin, Li Zheng, Liu Jie
Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.
Cell Prolif. 2015 Jun;48(3):271-7. doi: 10.1111/cpr.12179. Epub 2015 Mar 3.
Primary cutaneous lymphomas (PCL) compose a heterogeneous disease with still unknown aetiology and mechanisms of development. MicroRNAs (miRNAs) have recently been discovered as one of the crucial players in PCL carcinogenesis through post-transcriptional regulation of gene expression. miRNAs have been reported to be frequently deregulated in PCLs and their biological significance has been further confirmed in multiple functional experiments. Such studies help us understand molecular pathogenesis of PCL. In this review, we summarize expression of miRNAs and their corresponding roles in different subtypes of PCL. With expression and functional role of miRNAs revealed, investigation of their possible clinical use as biomarkers for diagnosis, prediction of prognosis and target for therapies, will be a promising area in the future.
原发性皮肤淋巴瘤（PCL）是一种病因和发病机制尚不清楚的异质性疾病。微小RNA（miRNA）最近被发现是PCL致癌过程中的关键因素之一，它通过对基因表达的转录后调控发挥作用。据报道，miRNA在PCL中经常失调，并且其生物学意义在多个功能实验中得到了进一步证实。这些研究有助于我们了解PCL的分子发病机制。在这篇综述中，我们总结了miRNA在PCL不同亚型中的表达及其相应作用。随着miRNA的表达和功能作用被揭示，研究它们作为诊断生物标志物、预后预测指标和治疗靶点的潜在临床应用，将是未来一个有前景的领域。
