Jiang Chenyu, Xu Yunlong, Zhong Jiafeng, Wu Junyan, He Jian, Xu Wei, Zhu Yingjie
Shenzhen Key Laboratory of Drug Addiction, Shenzhen Neher Neural Plasticity Laboratory, The Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Chinese Academy of Sciences, Shenzhen, China.
College of Life Science, University of Chinese Academy of Sciences, Beijing, China.
Front Mol Neurosci. 2022 Jul 11;15:934167. doi: 10.3389/fnmol.2022.934167. eCollection 2022.
Methamphetamine is a highly addictive drug and its abuse leads to serious health and social problems. Until now, no effective medications are yet available for the treatment of methamphetamine addiction. Our study reveals that chloral hydrate, a clinical sedative drug, suppresses the seeking desire for methamphetamine. After 5 days of continuous administration (subanesthetic dose 50 mg/kg and 100 mg/kg), methamphetamine-seeking behavior of rats was inhibited in the condition place preference and intravenous self-administration tests. Furthermore, chloral hydrate treatment robustly suppressed cue-induced methamphetamine relapse. The whole brain c-fos immunostaining revealed that chloral hydrate treatment suppressed neuronal activity in the rhomboid thalamic nucleus (Rh), dorsal endopiriform nucleus (dEn), and claustrum (Cl) while enhanced zona incerta (ZI) activity during cue-induced methamphetamine relapse. Therefore, chloral hydrate could remodel neural network activity and serve as a potential medicine to treat methamphetamine addiction.
甲基苯丙胺是一种极易成瘾的药物，其滥用会导致严重的健康和社会问题。到目前为止，尚无有效的药物可用于治疗甲基苯丙胺成瘾。我们的研究表明，临床镇静药物水合氯醛可抑制对甲基苯丙胺的渴求。连续给药5天（亚麻醉剂量50mg/kg和100mg/kg）后，在条件性位置偏爱和静脉自身给药试验中，大鼠的觅药行为受到抑制。此外，水合氯醛治疗可有力地抑制线索诱导的甲基苯丙胺复吸。全脑c-fos免疫染色显示，在线索诱导的甲基苯丙胺复吸过程中，水合氯醛治疗抑制了菱形丘脑核（Rh）、背内梨状核（dEn）和屏状核（Cl）中的神经元活动，同时增强了未定带（ZI）的活动。因此，水合氯醛可重塑神经网络活动，并有望成为治疗甲基苯丙胺成瘾的药物。
