a Department of Surgery , Guangzhou Medical University , Guangzhou , P. R. China.
b Department of Sports medicine , Shenzhen Second People's Hospital (First Affiliated Hospital of Shenzhen University) , Shenzhen, Guangdong , P. R. China.
Artif Cells Nanomed Biotechnol. 2015;43(6):361-5. doi: 10.3109/21691401.2014.893521. Epub 2014 Mar 14.
To study the clinical effect of bone defect treated with nano-hydroxyapatite(Nano-HA) artificial bone.
From September 2009 to June 2012, 27 cases of bone defect were analyzed retrospectively. The position of bone defect included humerus, radius, ulna, femur, tibia and calcaneus. The range of bone defect was from 0.3 × 1.0 cm to 3 × 6.5 cm. Among them, there were 22 cases with fractures and 5 cases with tumors. All patients were treated with Nano-HA artificial bone. The ability of bone defect repair was evaluated by X-ray exams performed preoperatively and postoperatively. HSS scores were adopted for final evaluation at the latest follow-up.
The patients were followed up from 11 to 26 months (average of 18.5 months). No general side effects occurred. X-ray photo showed an integrity interface between Nano-HA and bone. Primary healing was obtained in all cases without any complication.
The Nano-HA artificial bone had a good biocompatibility and could be an ideal artificial bone in the reconstruction of bone defect.
研究纳米羟基磷灰石（Nano-HA）人工骨治疗骨缺损的临床效果。
回顾性分析 2009 年 9 月至 2012 年 6 月收治的 27 例骨缺损患者。骨缺损部位包括肱骨、桡骨、尺骨、股骨、胫骨和跟骨。骨缺损范围为 0.3×1.0cm 至 3×6.5cm。其中骨折 22 例，肿瘤 5 例。所有患者均采用纳米羟基磷灰石人工骨治疗。术前及术后 X 线检查评估骨缺损修复能力，末次随访采用 HSS 评分进行评估。
患者随访 11~26 个月，平均 18.5 个月。无全身不良反应。X 线片显示 Nano-HA 与骨之间有完整的界面。所有病例均获得一期愈合，无任何并发症。
纳米羟基磷灰石人工骨具有良好的生物相容性，是骨缺损重建的理想人工骨。
