Zhou Lei, Hu Chunjie, Chen Yingjun, Xia Shiqi, Yan Jinglong
Department of Orthopedics, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150081, China.
Department of Obstetrics and Gynecology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, 150081, China.
J Orthop Surg Res. 2017 Feb 21;12(1):32. doi: 10.1186/s13018-017-0529-8.
This study aimed to investigate the effects of silk fiber (SF)/calcium phosphate cement (CPC) biocomposite on repairing radial bone defects in rabbits.
Four-month-old New Zealand rabbits were selected to create a bilateral radial bone defect model and divided into four groups according to implanted material: SF/CPC, SF/CPC/particulate bone (PB), PB, and control (C). The specimens were removed at four and eight postoperative weeks for general observation, X-ray examination, tissue slicing, scanning electron microscopy (SEM), and biomechanical testing.
Postoperative X-ray showed no bone defect repair in group C and different degrees of bone defect repair in the other three groups. Imaging, histology, and SEM showed the following: group SF/CPC formed fine trabecular bone in week 4, while the maximum bending load in group SF/CPC in week 4 was significantly different from those in the other groups (P < 0.05).
SF/CPC has good biocompatibility and bone-inducing ability, demonstrating its bone defect-repairing ability.
本研究旨在探讨丝素纤维（SF）/磷酸钙骨水泥（CPC）生物复合材料对兔桡骨缺损的修复作用。
选取4月龄新西兰兔建立双侧桡骨缺损模型，并根据植入材料分为四组：SF/CPC组、SF/CPC/颗粒骨（PB）组、PB组和对照组（C组）。术后4周和8周取出标本进行大体观察、X线检查、组织切片、扫描电子显微镜（SEM）检查及生物力学测试。
术后X线显示，C组无骨缺损修复，其他三组有不同程度的骨缺损修复。影像学、组织学和SEM检查结果如下：SF/CPC组在第4周形成了细密的小梁骨，且第4周时SF/CPC组的最大弯曲载荷与其他组相比有显著差异（P < 0.05）。
SF/CPC具有良好的生物相容性和骨诱导能力，显示出其修复骨缺损的能力。
