钯催化芳基炔基羧酸的脱羧三氟乙基化反应。

Palladium-catalyzed decarboxylative trifluoroethylation of aryl alkynyl carboxylic acids.

作者信息

Hwang Jinil, Park Kyungho, Choe Juseok, Min Hongkeun, Song Kwang Ho, Lee Sunwoo

机构信息

Department of Chemistry, Chonnam National University , Gwangju 500-757, Republic of Korea.

出版信息

J Org Chem. 2014 Apr 4;79(7):3267-71. doi: 10.1021/jo5003032. Epub 2014 Mar 26.

DOI:10.1021/jo5003032

PMID:24628537

Abstract

A trifluoroethylation of alkynes through a palladium-catalyzed decarboxylative coupling reaction was developed. When alkynyl carboxylic acids and ICH2CF3 were allowed to react with [Pd(η(3)-allyl)Cl]2/XantPhos and Cs2CO3 in N,N-dimethylformamide (DMF) at 80 °C for 1 h, the desired products were formed in good yields. This catalytic system showed high functional group tolerance.

摘要

通过钯催化的脱羧偶联反应开发了一种炔烃的三氟乙基化反应。当炔基羧酸和ICH2CF3与[Pd(η(3)-烯丙基)Cl]2/XantPhos和Cs2CO3在N，N-二甲基甲酰胺（DMF）中于80°C反应1小时时，以良好的产率形成所需产物。该催化体系显示出高官能团耐受性。