Barker J N, Navsaria H A, Leigh I M, MacDonald D M
Laboratory of Applied Dermatopathology, United Medical School, Guy's Hospital, London, U.K.
Br J Dermatol. 1988 Nov;119(5):567-72. doi: 10.1111/j.1365-2133.1988.tb03466.x.
Experiments were performed to examine the hypothesis that the surface expression of HLA-DR by keratinocytes in certain disease states is conferred by the activity of gamma-interferon, derived from dermal activated T lymphocytes. In vivo studies revealed a spatial relationship between keratinocyte HLA-DR expression and activated T lymphocytes within the dermal inflammatory infiltrate. In vitro studies confirmed that gamma-interferon can induce keratinocyte synthesis of HLA-DR. These results suggest that, in vivo, gamma-interferon produced by activated T lymphocytes induces keratinocyte HLA-DR synthesis and expression.
在某些疾病状态下，角质形成细胞表面HLA - DR的表达是由源自真皮活化T淋巴细胞的γ干扰素的活性所赋予的。体内研究揭示了角质形成细胞HLA - DR表达与真皮炎症浸润内活化T淋巴细胞之间的空间关系。体外研究证实γ干扰素可诱导角质形成细胞合成HLA - DR。这些结果表明，在体内，活化T淋巴细胞产生的γ干扰素诱导角质形成细胞合成和表达HLA - DR。
