Department of Neurology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan; College of Medicine, National Taiwan University, Taipei, Taiwan; College of Medicine, Taipei Medical University, Taipei, Taiwan.
Eur J Neurol. 2014 Jun;21(6):907-13. doi: 10.1111/ene.12410. Epub 2014 Mar 17.
To investigate the spectrum and risks of accidental injuries (AIs) amongst Parkinson disease (PD) patients.
The participants comprised PD patients aged 50 years and older who were initially diagnosed between 2000 and 2009, and a comparison group of non-PD patients. The incidence rates of accidental injury types amongst PD and non-PD patients were calculated; hazard ratios were calculated and adjusted for comorbidities, using 95% confidence intervals (CIs) of developing such outcomes in PD patients.
In total, 4046 PD patients and 16 184 non-PD patients were followed over time. The PD patients demonstrated the following incidence rates and hazard ratios in comparison to the control cohort for accidental injuries: all injuries, 19.78 per 100 person-years (100 PYs), adjusted hazard ratio (HR) 1.30 (95% CI 1.24-1.36); head injury, 2.95 per 100 PYs, HR 1.88 (95% CI 1.64-2.15); bone fracture and dislocation, 4.61 per 100 PYs, HR 1.39 (95% CI 1.25-1.54); burns, 0.66 per 100 PYs, HR 1.01 (95% CI 0.78-1.32); injury to spinal cord, plexus and nerves, 0.15 per 100 PYs, HR 1.25 (95% CI 0.72-2.17); superficial injuries and contusions, 11.41 per 100 PYs, HR 1.20 (95% CI 1.12-1.27). The injury risk for the 69-79 years age group in PD compared with controls of the same age (HR 1.38) was significantly higher compared with that of the 50-69 age groups in PD and controls (HR 1.16).
Parkinson disease patients demonstrate a significantly elevated risk of developing all accidental injury types except burn injuries and injuries to spinal cord, plexus and nerves, compared with age-matched controls. The risk increases as age increases.
调查帕金森病（PD）患者意外伤害（AIs）的类型和风险。
纳入的研究对象为 2000 年至 2009 年间确诊的年龄≥50 岁的 PD 患者，以及对照组非 PD 患者。计算 PD 和非 PD 患者的意外伤害类型发生率；使用 PD 患者发生此类结局的 95%置信区间（CI）计算风险比（HR）并进行调整，以调整合并症。
共随访 4046 例 PD 患者和 16184 例非 PD 患者。与对照组相比，PD 患者的意外伤害发生率和 HR 如下：所有损伤 19.78/100 人年（100 PYs），调整 HR 1.30（95%CI 1.24-1.36）；头部损伤 2.95/100 PYs，HR 1.88（95%CI 1.64-2.15）；骨骨折和脱位 4.61/100 PYs，HR 1.39（95%CI 1.25-1.54）；烧伤 0.66/100 PYs，HR 1.01（95%CI 0.78-1.32）；脊髓、神经丛和神经损伤 0.15/100 PYs，HR 1.25（95%CI 0.72-2.17）；浅表损伤和挫伤 11.41/100 PYs，HR 1.20（95%CI 1.12-1.27）。与同年龄对照组相比，PD 患者中 69-79 岁年龄组的损伤风险（HR 1.38）明显高于 PD 患者中 50-69 岁年龄组和对照组（HR 1.16）。
与年龄匹配的对照组相比，PD 患者发生所有意外伤害类型的风险显著升高，除烧伤和脊髓、神经丛和神经损伤外。风险随年龄增长而增加。
