Division of Preventive, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, 1-1 Mukaihata-cho, Fushimi-ku, 612-8555 Kyoto, Japan.
Division of Preventive, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, 1-1 Mukaihata-cho, Fushimi-ku, 612-8555 Kyoto, Japan; Division of Community and Family Medicine, Center for Community Medicine, Jichi Medical University, Tochigi, Japan.
Ann Endocrinol (Paris). 2014 Feb;75(1):25-8. doi: 10.1016/j.ando.2014.01.003. Epub 2014 Mar 12.
Soy isoflavones have received great attention for their beneficial effects on health and disease, i.e., in patients with diabetes. Equol is a biologically active isoflavone-related metabolite with interindividual differences in its production. The current study investigated the relationship between an equol-producing state and the levels of adipocytokine markers in a prediabetic and diabetic population.
A total of 79 subjects (34 males/45 females) in a prediabetic or diabetic state recruited from the general population were examined regarding their ability to produce equol using urine samples. Clinical data, such as age, smoking as well as anthropometric and biochemical variables, including body mass index (BMI), lipids, insulin, glucose, hemoglobin A1c, leptin and adiponectin, were recorded.
Equol producers exhibited lower leptin and leptin/BMI than non-producers among females. Simple correlation tests and stepwise multiple regression analyses revealed a significant inverse correlation between the leptin/BMI and equol-production. This relationship was not found in males.
Female equol producers can have favorable metabolic traits in relation to leptin metabolism in this population. Further studies are needed to confirm these results.
大豆异黄酮因其对健康和疾病的有益作用而受到广泛关注，例如在糖尿病患者中。雌马酚是一种具有个体差异的生物活性异黄酮相关代谢物。本研究调查了在糖尿病前期和糖尿病人群中，产生雌马酚的状态与脂肪细胞因子标志物水平之间的关系。
从普通人群中招募了 79 名处于糖尿病前期或糖尿病状态的受试者（男性 34 名/女性 45 名），并使用尿液样本检查其产生雌马酚的能力。记录了临床数据，如年龄、吸烟以及人体测量学和生化变量，包括体重指数（BMI）、脂质、胰岛素、血糖、糖化血红蛋白、瘦素和脂联素。
女性中，雌马酚产生者的瘦素和瘦素/BMI 低于非产生者。简单相关测试和逐步多元回归分析显示，瘦素/BMI 与雌马酚产生之间存在显著的负相关关系。在男性中未发现这种关系。
在该人群中，女性雌马酚产生者的瘦素代谢可能具有有利的代谢特征。需要进一步的研究来证实这些结果。
