Magidson Jessica F, Blashill Aaron J, Wall Melanie M, Balan Ivan C, Wang Shuai, Lejuez C W, Blanco Carlos
Massachusetts General Hospital/Harvard Medical School, Boston, MA, United States; University of Maryland, College Park, MD, United States.
Massachusetts General Hospital/Harvard Medical School, Boston, MA, United States.
J Psychosom Res. 2014 Apr;76(4):322-8. doi: 10.1016/j.jpsychores.2013.12.009. Epub 2014 Jan 3.
Sexually transmitted diseases (STDs) are a significant public health concern. Numerous internalizing and externalizing psychiatric disorders have been found to be related to STD risk. However, to date, no studies have examined several psychiatric disorders simultaneously to account for STD risk. Given that psychiatric disorders often co-occur and can be explained by a limited number of latent dimensions of psychopathology, it is important to examine whether the relationship between STDs and psychiatric disorders is best explained by broad dimensions of psychopathology.
The current study examined the associations between a range of Axis I and II psychiatric disorders at baseline and rates of STDs at a three-year follow-up in a large, nationally representative sample of adults in the United States (n=34,434). A confirmatory factor analysis (CFA) was conducted to fit three factors, two internalizing and one externalizing. Structural equation modeling (SEM) was used to assess the relationships between and among the factors and STD status and to test for mediation.
In bivariate analyses, most Axis I and Axis II disorders were associated with STD diagnosis at Wave 2, whereas the results of the structural model showed that only the externalizing factor was significantly associated with STD diagnosis at Wave 2. Further, the externalizing factor mediated the relationship between one of the internalizing factors and STD diagnosis.
Findings suggest the unique contribution of externalizing psychopathology to STD risk and the importance of examining latent dimensions of disorders when understanding this relationship between psychiatric disorders and STDs.
性传播疾病(STD)是一个重大的公共卫生问题。已发现许多内化和外化精神障碍与性传播疾病风险相关。然而,迄今为止,尚无研究同时考察多种精神障碍以解释性传播疾病风险。鉴于精神障碍常常共病,且可由有限数量的精神病理学潜在维度来解释,因此考察性传播疾病与精神障碍之间的关系是否最好由精神病理学的宽泛维度来解释很重要。
本研究在美国一个具有全国代表性的大型成年样本(n = 34434)中,考察了基线时一系列轴I和轴II精神障碍与三年随访时性传播疾病发生率之间的关联。进行了验证性因素分析(CFA)以拟合三个因素,两个内化因素和一个外化因素。使用结构方程模型(SEM)来评估各因素之间以及与性传播疾病状态之间的关系,并进行中介检验。
在双变量分析中,大多数轴I和轴II障碍与第2波时的性传播疾病诊断相关,而结构模型的结果表明,只有外化因素与第2波时的性传播疾病诊断显著相关。此外,外化因素介导了其中一个内化因素与性传播疾病诊断之间的关系。
研究结果表明外化精神病理学对性传播疾病风险有独特贡献,并且在理解精神障碍与性传播疾病之间的这种关系时,考察障碍的潜在维度很重要。