Schellekens A F A, de Jong C A J, Buitelaar J K, Verkes R J
Radboud Medical Centre Nijmegen, Department of Psychiatry, 966, PO Box 9101, Reinier Postlaan 10, 6500 HB, Nijmegen, The Netherlands; Nijmegen Institute for Science Practitioners in Addiction (NISPA).
Nijmegen Institute for Science Practitioners in Addiction (NISPA).
Eur Psychiatry. 2015 Jan;30(1):128-36. doi: 10.1016/j.eurpsy.2013.08.006. Epub 2014 Mar 12.
Alcohol dependence and anxiety disorders often co-occur. Yet, the effect of co-morbid anxiety disorders on the alcohol relapse-risk after treatment is under debate. This study investigated the effect of co-morbid anxiety disorders on relapse rates in alcohol dependence. We hypothesized that co-morbid anxiety disorders would be particularly predictive for early relapse, but not late relapse.
In a prospective design, male alcohol dependent patients (n=189) were recruited from an inpatient detoxification clinic. Psychiatric diagnoses and personality traits were assessed using the Mini International Neuropsychiatric Interview for psychiatric disorders and the Temperament and Character Inventory. The addiction severity index was used to assess addiction severity and follow-up.
One year after detoxification, 81 patients (53%) relapsed and nine patients (7%) were deceased, due to alcohol related causes. Co-morbid anxiety disorder, marital status, addiction severity, in particular legal problems, and harm avoidance predicted relapse. Anxiety disorders specifically predicted early relapse.
Alcohol dependence is a severe mental disorder, with high relapse rates and high mortality. Alcohol dependent patients with co-morbid anxiety disorders are particularly prone to relapse during the first three months of treatment. These patients may therefore require additional medical and psychological attention.
酒精依赖和焦虑症常常同时出现。然而，共病焦虑症对治疗后酒精复发风险的影响仍存在争议。本研究调查了共病焦虑症对酒精依赖复发率的影响。我们假设共病焦虑症对早期复发具有特别的预测性，但对晚期复发则不然。
采用前瞻性设计，从一家住院戒毒诊所招募了189名男性酒精依赖患者。使用针对精神疾病的迷你国际神经精神访谈和气质与性格量表评估精神疾病诊断和人格特质。成瘾严重程度指数用于评估成瘾严重程度和随访情况。
戒毒一年后，81名患者（53%）复发，9名患者（7%）因与酒精相关的原因死亡。共病焦虑症、婚姻状况、成瘾严重程度，特别是法律问题以及避免伤害的倾向可预测复发。焦虑症尤其能预测早期复发。
酒精依赖是一种严重的精神障碍，复发率高且死亡率高。患有共病焦虑症的酒精依赖患者在治疗的前三个月特别容易复发。因此，这些患者可能需要额外的医疗和心理关注。
