Meier S, Priest N V, Burke C R, Kay J K, McDougall S, Mitchell M D, Walker C G, Heiser A, Loor J J, Roche J R
DairyNZ Limited, Private Bag 3221, Hamilton, New Zealand 3240.
Cognosco, Anexa Animal Health, PO Box 21, Morrinsville 3300, New Zealand.
J Dairy Sci. 2014 May;97(5):2932-43. doi: 10.3168/jds.2013-7838. Epub 2014 Mar 13.
Previous research results have indicated an increase in pregnancy rate in pasture-grazed cows treated with a nonsteroidal antiinflammatory drug (NSAID) 3 to 4 wk postcalving, when a high proportion of nucleated cells from within the uterus were polymorphonucleated; however, no effect on milk production was detected. It was hypothesized that this lack of effect on milk production was because the administration of the NSAID was too late after calving. The aims of the current study were to evaluate the timing of administering a propionic acid-derived NSAID (i.e., carprofen) on milk production, metabolic status, uterine health, and reproductive performance. Six-hundred and thirty-nine cows (134 primiparous and 505 multiparous) calving between July 4 and September 5, 2012, in 2 herds (herd 1: n=228; herd 2: n=411) were enrolled. Using a randomized block design, cows were allocated to 1 of 3 treatment groups as they calved: (1) no treatment (control; n=221), (2) NSAID administered on d 1, 3, and 5 postcalving (early; n=214), and (3) NSAID administered on d 19, 21, and 23 postcalving (late; n=204). Milk production and composition, and body condition were determined weekly. Blood was sampled at 4 time points (1 precalving and 3 postcalving) to determine the effects of treatment on indicators of metabolic health and energy status. Uterine health was determined by measuring the proportion of nucleated cells that were polymorphonucleated following cytobrush sampling of the uterus between d 13 to 24 and d 30 to 49 postcalving. Irrespective of timing of application, NSAID did not affect milk production, body weight, or body condition during early lactation. Treatment with an NSAID 19 to 23 d postcalving increased the proportion of cows submitted for breeding during the first 3 wk of the seasonal breeding program (control: 85%, early: 83%, and late: 92%), but did not affect conception or pregnancy rates. No detectable effect of treatment on uterine health or circulating metabolites and minerals existed, although cows in the early NSAID treatment group had marginally lower serum β-hydroxybutyrate concentrations (0.1 mmol/L) than the other groups between 2 and 26 d in milk. In conclusion, administration of this particular NSAID at either 1 or 3 wk after calving did not improve milk production, indicators of health, or reproductive performance.
先前的研究结果表明，在产犊后3至4周用非甾体抗炎药（NSAID）治疗的放牧奶牛，其妊娠率有所提高，此时子宫内有很大比例的有核细胞为多形核细胞；然而，未检测到对产奶量有影响。据推测，对产奶量缺乏影响是因为产犊后给予NSAID的时间太晚。本研究的目的是评估给予丙酸类NSAID（即卡洛芬）的时间对产奶量、代谢状态、子宫健康和繁殖性能的影响。纳入了2012年7月4日至9月5日在2个牛群（牛群1：n = 228；牛群2：n = 411）中产犊的639头奶牛（134头初产牛和505头经产牛）。采用随机区组设计，奶牛在产犊时被分配到3个处理组中的1组：（1）不治疗（对照组；n = 221），（2）在产犊后第1、3和5天给予NSAID（早期组；n = 214），以及（3）在产犊后第19、21和23天给予NSAID（晚期组；n = 204）。每周测定产奶量和组成以及体况。在4个时间点（1个产犊前和3个产犊后）采集血液，以确定处理对代谢健康和能量状态指标的影响。通过在产犊后第13至24天和第30至49天对子宫进行细胞刷采样，测量多形核有核细胞的比例来确定子宫健康状况。无论给药时间如何，NSAID在泌乳早期均不影响产奶量、体重或体况。在季节性繁殖计划的前3周，产犊后19至23天用NSAID治疗增加了送去配种的奶牛比例（对照组：85%，早期组：83%，晚期组：92%），但不影响受孕率或妊娠率。虽然在产奶2至26天期间，早期NSAID治疗组的奶牛血清β-羟基丁酸浓度比其他组略低（0.1 mmol/L），但未检测到处理对子宫健康或循环代谢物和矿物质有影响。总之，在产犊后1周或3周给予这种特定的NSAID并不能提高产奶量、健康指标或繁殖性能。
