Discipline of Medicine, University of Adelaide, Adelaide, Australia; NHMRC Center of Research Excellence in Translating Nutritional Science to Good Health, University of Adelaide, Adelaide, Australia.
Discipline of Medicine, University of Adelaide, Adelaide, Australia; NHMRC Center of Research Excellence in Translating Nutritional Science to Good Health, University of Adelaide, Adelaide, Australia.
J Am Med Dir Assoc. 2014 Jun;15(6):394-409. doi: 10.1016/j.jamda.2014.01.011. Epub 2014 Mar 13.
Postprandial hypotension (PPH) is an important clinical problem, which has received inappropriately little attention.
A systematic search of the databases PubMed, Embase, Cochrane Library, and Web of Knowledge, from their inception to the present time, was conducted to identify studies relevant to the epidemiology, pathophysiology, and/or management of PPH.
A total of 417 full-text papers were retrieved from database searching and, following screening, 248 were retained. Of these, 167 papers were considered eligible for inclusion.
PPH occurs commonly in older people and represents a major cause of morbidity. Although the pathophysiology of PPH remains poorly defined, diverse factors, including impairments in sympathetic and baroreflex function, release of vasodilatory peptides, the rate of small intestinal nutrient delivery, gastric distension, and splanchnic blood pooling, appear important. Current pharmacologic and nonpharmacologic management is suboptimal. Research into the pathophysiology of PPH represents a priority so that management can be targeted more effectively.
餐后低血压（PPH）是一个重要的临床问题，但受到的关注不够。
系统检索了 PubMed、Embase、Cochrane 图书馆和 Web of Knowledge 数据库，从建库到现在，以确定与 PPH 的流行病学、病理生理学和/或管理相关的研究。
从数据库检索中总共检索到 417 篇全文论文，经过筛选，保留了 248 篇。其中，有 167 篇被认为符合纳入标准。
PPH 常见于老年人，是发病率的主要原因。尽管 PPH 的病理生理学仍未得到明确界定，但包括交感和压力反射功能障碍、血管舒张肽释放、小肠营养输送速度、胃扩张和内脏血液淤积在内的多种因素似乎很重要。目前的药物和非药物治疗并不理想。研究 PPH 的病理生理学是当务之急，以便更有效地进行治疗。
