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Differential effects of calcium channel blockers and stimulants on morphine withdrawal in vitro.

作者信息

Barrios M, Baeyens J M

机构信息

Department of Pharmacology, University of Granada Medical School, Spain.

出版信息

Eur J Pharmacol. 1988 Jul 26;152(1-2):175-8. doi: 10.1016/0014-2999(88)90852-7.

DOI:10.1016/0014-2999(88)90852-7
PMID:2463173
Abstract

The effects of calcium channel blockers and stimulants on naloxone-precipitated morphine withdrawal in morphine-dependent ileum were evaluated in vitro. Both verapamil and diltiazem (0.01-1 microM) inhibited the naloxone-induced morphine withdrawal contractures in a concentration-dependent way. The effect of diltiazem was stereo-specific. On the other hand, the calcium channel stimulant, Bay k 8644 (0.01 microM), significantly increased the naloxone-induced contractures of morphine-dependent ileum. These results suggest a role for calcium channels in morphine withdrawal in vitro.

摘要

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