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[苏联新型抗心律失常制剂阿拉平宁的药代动力学和药效学]

[The pharmacokinetics and pharmacodynamics of the new Soviet anti-arrhythmia preparation allapinin].

作者信息

Abdalla A, Rulin V A, Mazur N A, Chikovani S I

出版信息

Farmakol Toksikol. 1988 Sep-Oct;51(5):47-9.

PMID:2463182
Abstract

Pharmacokinetics and pharmacodynamics of a new antiarrhythmic drug allapinin was studied in patients with frequent ventricular and supraventricular extrasystoles. The technique of determining allapinin by high performance liquid chromatography is described. Intravenous administration of the drug in a dose of 20 mg was shown to be effective in 50% of patients.

摘要

在频发室性及室上性早搏患者中研究了新型抗心律失常药物阿拉平宁的药代动力学和药效学。描述了用高效液相色谱法测定阿拉平宁的技术。静脉注射20毫克剂量的该药物在50%的患者中显示有效。

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