单次口服阿拉皮宁对慢性室性早搏患者的疗效

[Effect of a single oral dose of allapinin in patients with chronic ventricular extrasystole].

作者信息

Sokolov S F, Alikhanov G N, Golitsyn S P, Koltunova M I, Smetnev A S

出版信息

Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR. 1989;12(1):36-42.

Abstract

Effect of a new antiarrhythmic drug allapinin was studied in 21 patients with chronic ventricular extrasystoles by an acute drug test with single oral dose of the drug controlled by 12-hour Holter monitoring. In 9 cases the dose was 50 mg. Maximal total reduction of ventricular ectopic complexes (VEC) per hour was 67 +/- 28% (mean value); in 5 cases (55%) it exceeded 90% of basal level. At peak of action, PQ interval increased by 15%, QRS--by 14%, QT was not significantly changed. In 14 cases the dose was 75 micrograms. Maximal VEC number reduction per hour was on the average 89 +/- 18% and in 12 cases (88%) exceeded 90%. PQ increased by 22%, QRS--by 23% and QT by 9% though JT was not changed (average peak values). It is thus concluded that single oral dose of allapinin has pronounced antiarrhythmic effect in patients with VEC and influences ECG intervals in the way characteristic for class IC antiarrhythmic drugs. The degree of the effect depends on the dose.

摘要

采用单次口服药物的急性药物试验，并通过12小时动态心电图监测，对21例慢性室性早搏患者研究了一种新型抗心律失常药物阿拉平宁的疗效。9例患者服用剂量为50毫克。每小时室性异位搏动（VEC）的最大总减少率为67±28%（平均值）；5例（55%）超过基础水平的90%。在作用峰值时，PQ间期增加15%，QRS间期增加14%，QT间期无明显变化。14例患者服用剂量为75微克。每小时VEC数量的最大减少率平均为89±18%，12例（88%）超过90%。PQ间期增加22%，QRS间期增加23%，QT间期增加9%，尽管JT间期未改变（平均峰值）。由此得出结论，单次口服阿拉平宁对室性早搏患者有显著的抗心律失常作用，并以IC类抗心律失常药物特有的方式影响心电图间期。疗效程度取决于剂量。