Mathieu Olivier, Bouché Nicolas
Clermont Université, Université Blaise Pascal, GReD, BP 10448, F-63000 Clermont-Ferrand, France; CNRS, UMR 6293, GReD, F-63001 Clermont-Ferrand, France; INSERM, UMR 1103, GReD, F-63001 Clermont-Ferrand, France.
INRA, UMR 1318, Institut Jean-Pierre Bourgin, RD10, F-78000 Versailles, France; AgroParisTech, Institut Jean-Pierre Bourgin, RD10, F-78000 Versailles, France.
Curr Opin Plant Biol. 2014 Apr;18:60-5. doi: 10.1016/j.pbi.2014.02.006. Epub 2014 Mar 15.
The processing of pre-mRNAs, including the selection of polyadenylation sites, is influenced by the surrounding chromatin context. We review here recent studies in Arabidopsis thaliana highlighting the intricate and reciprocal interplay between chromatin state and RNA processing. The studies have revealed that transcription can be influenced by the presence, in gene introns, of combination of epigenetic marks typical of heterochromatin. New factors binding to these marks have been identified and shown to play key roles in controlling the use of polyadenylation sites and processing of functional mRNAs. Concomitantly, several proteins of both the splicing and the polyadenylation machineries are also emerging as regulators of DNA methylation patterns and chromatin silencing.
前体mRNA的加工，包括聚腺苷酸化位点的选择，受周围染色质环境的影响。我们在此综述拟南芥中的最新研究，这些研究突出了染色质状态与RNA加工之间复杂且相互的作用。这些研究表明，基因内含子中异染色质典型表观遗传标记的组合的存在可影响转录。已鉴定出与这些标记结合的新因子，并表明它们在控制聚腺苷酸化位点的使用和功能性mRNA的加工中起关键作用。与此同时，剪接和聚腺苷酸化机制中的几种蛋白质也正在成为DNA甲基化模式和染色质沉默的调节因子。
