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spliceR: an R package for classification of alternative splicing and prediction of coding potential from RNA-seq data.spliceR：一个用于 RNA-seq 数据中可变剪接分类和编码潜力预测的 R 包。
BMC Bioinformatics. 2014 Mar 23;15:81. doi: 10.1186/1471-2105-15-81.
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Genome-guided transcript assembly by integrative analysis of RNA sequence data.通过RNA序列数据的综合分析进行基因组引导的转录本组装。
Nat Biotechnol. 2014 Apr;32(4):341-6. doi: 10.1038/nbt.2850. Epub 2014 Mar 16.
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Interplay between chromatin and RNA processing.染色质与RNA加工之间的相互作用。
Curr Opin Plant Biol. 2014 Apr;18:60-5. doi: 10.1016/j.pbi.2014.02.006. Epub 2014 Mar 15.
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Transcription: splicing keeps RNA polymerase II in check.转录：剪接可控制RNA聚合酶II。
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microRNAs in cardiovascular diseases: current knowledge and the road ahead.微小 RNA 在心血管疾病中的作用：当前的认识和未来的方向。
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FineSplice, enhanced splice junction detection and quantification: a novel pipeline based on the assessment of diverse RNA-Seq alignment solutions.FineSplice，增强的剪接接头检测和定量：一种基于多种 RNA-Seq 比对解决方案评估的新型管道。
Nucleic Acids Res. 2014 Apr;42(8):e71. doi: 10.1093/nar/gku166. Epub 2014 Feb 25.
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The long noncoding RNA CHRF regulates cardiac hypertrophy by targeting miR-489.长链非编码 RNA CHRF 通过靶向 miR-489 调节心肌肥厚。
Circ Res. 2014 Apr 25;114(9):1377-88. doi: 10.1161/CIRCRESAHA.114.302476. Epub 2014 Feb 20.
8
Pressure-overload cardiac hypertrophy is associated with distinct alternative splicing due to altered expression of splicing factors.压力超负荷性心脏肥大与剪接因子表达改变导致的不同选择性剪接有关。
Mol Cells. 2014 Jan;37(1):81-7. doi: 10.14348/molcells.2014.2337. Epub 2014 Jan 27.
9
lncRNAMap: a map of putative regulatory functions in the long non-coding transcriptome.lncRNAMap：长链非编码转录组中假定调控功能图谱。
Comput Biol Chem. 2014 Jun;50:41-9. doi: 10.1016/j.compbiolchem.2014.01.003. Epub 2014 Jan 23.
10
[Metoprolol attenuates pressure overload-induced myocardial hypertrophy through modulating Dryk1A-ASF-CaMKIIδ signaling pathways].[美托洛尔通过调节Dryk1A-ASF-CaMKIIδ信号通路减轻压力超负荷诱导的心肌肥大]
Zhonghua Xin Xue Guan Bing Za Zhi. 2013 Dec;41(12):1029-33.

心脏发育与疾病中的转录组复杂性——基因组与表型组之间不断扩展的领域

Transcriptome complexity in cardiac development and diseases--an expanding universe between genome and phenome.

作者信息

Gao Chen, Wang Yibin

机构信息

Departments of Anesthesiology, Physiology and Medicine, Molecular Biology Institute, David Geffen School of Medicine at University of California at Los Angeles.

出版信息

Circ J. 2014;78(5):1038-47. doi: 10.1253/circj.cj-14-0412. Epub 2014 Apr 22.

DOI:10.1253/circj.cj-14-0412
PMID:24759793
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4306672/
Abstract

With the advancement of transcriptome profiling by micro-arrays and high-throughput RNA-sequencing, transcriptome complexity and its dynamics are revealed at different levels in cardiovascular development and diseases. In this review, we will highlight the recent progress in our knowledge of cardiovascular transcriptome complexity contributed by RNA splicing, RNA editing and noncoding RNAs. The emerging importance of many of these previously under-explored aspects of gene regulation in cardiovascular development and pathology will be discussed.

摘要

随着微阵列和高通量RNA测序技术在转录组分析方面的进展，转录组的复杂性及其动态变化在心血管发育和疾病的不同层面得以揭示。在本综述中，我们将重点介绍RNA剪接、RNA编辑和非编码RNA对心血管转录组复杂性认识的最新进展。还将讨论这些以前未被充分探索的基因调控方面在心血管发育和病理学中的重要性。