心脏发育与疾病中的转录组复杂性——基因组与表型组之间不断扩展的领域
Transcriptome complexity in cardiac development and diseases--an expanding universe between genome and phenome.
作者信息
Gao Chen, Wang Yibin
机构信息
Departments of Anesthesiology, Physiology and Medicine, Molecular Biology Institute, David Geffen School of Medicine at University of California at Los Angeles.
出版信息
Circ J. 2014;78(5):1038-47. doi: 10.1253/circj.cj-14-0412. Epub 2014 Apr 22.
Abstract
With the advancement of transcriptome profiling by micro-arrays and high-throughput RNA-sequencing, transcriptome complexity and its dynamics are revealed at different levels in cardiovascular development and diseases. In this review, we will highlight the recent progress in our knowledge of cardiovascular transcriptome complexity contributed by RNA splicing, RNA editing and noncoding RNAs. The emerging importance of many of these previously under-explored aspects of gene regulation in cardiovascular development and pathology will be discussed.
摘要
随着微阵列和高通量RNA测序技术在转录组分析方面的进展，转录组的复杂性及其动态变化在心血管发育和疾病的不同层面得以揭示。在本综述中，我们将重点介绍RNA剪接、RNA编辑和非编码RNA对心血管转录组复杂性认识的最新进展。还将讨论这些以前未被充分探索的基因调控方面在心血管发育和病理学中的重要性。
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