Meenakshi C, Jayabal P, Ramakrishnan V
Department of Chemistry, Shri Meenakshi Government College for Women (Autonomous), Madurai 625 002, India.
Department of Laser Studies, School of Physics, Madurai Kamaraj University, Madurai 625 021, India.
Spectrochim Acta A Mol Biomol Spectrosc. 2014 Jun 5;127:172-6. doi: 10.1016/j.saa.2014.02.027. Epub 2014 Feb 22.
The thermodynamic property of the host-guest complexes formed between the curcumin, component of Indian Ayurvedic medicine turmeric, a drug molecule, with the supra molecule, p-t-butyl calix(8)arene was studied. p-t-Butyl calix(8)arene has been used as a host molecule and curcumin as a guest molecule. Optical absorption spectral studies were carried out to investigate the molecular recognition properties of p-t-butyl calix(8)arene with curcumin. The stochiometry of the host-guest complexes formed and the binding constant were determined. An interesting 1:1 and 4:1 stochiometric host-guest complexes were formed. Job's continuous method of variation and Benesi-Hildebrand expression were used for the determination of binding constant and the stochiometry of the host-guest complex formed.
研究了印度阿育吠陀药物姜黄的成分姜黄素（一种药物分子）与超分子对叔丁基杯[8]芳烃形成的主客体配合物的热力学性质。对叔丁基杯[8]芳烃被用作主体分子，姜黄素被用作客体分子。进行了光吸收光谱研究以研究对叔丁基杯[8]芳烃与姜黄素的分子识别特性。测定了形成的主客体配合物的化学计量比和结合常数。形成了有趣的1:1和4:1化学计量比的主客体配合物。采用乔布连续变化法和贝内西-希尔德布兰德表达式来测定结合常数和形成的主客体配合物的化学计量比。
