Soldano Alessia, Hassan Bassem A
VIB Center for the Biology of Disease, VIB, 3000 Leuven, Belgium; Center for Human Genetics, University of Leuven School of Medicine, 3000 Leuven, Belgium.
VIB Center for the Biology of Disease, VIB, 3000 Leuven, Belgium; Center for Human Genetics, University of Leuven School of Medicine, 3000 Leuven, Belgium.
Curr Opin Neurobiol. 2014 Aug;27:61-7. doi: 10.1016/j.conb.2014.02.003. Epub 2014 Mar 12.
Alzheimer's disease (AD) is the most common form of dementia among the elderly. Research in the AD field has been mostly focused on the biology of the Aβ peptide but increasing evidence is shifting attention toward the physiological role of APP as key to understanding AD pathology. It is becoming apparent that APP plays a central role in the mechanisms that guarantee the accuracy and the robustness of brain wiring. In the present review we explore APP functions with focus on some of the underlying molecular mechanisms.
阿尔茨海默病（AD）是老年人中最常见的痴呆形式。AD领域的研究大多集中在Aβ肽的生物学特性上，但越来越多的证据将注意力转向APP的生理作用，认为它是理解AD病理学的关键。越来越明显的是，APP在保证脑布线准确性和稳健性的机制中起着核心作用。在本综述中，我们重点探讨APP的功能及其一些潜在的分子机制。
