J Clin Pathol. 1988 Nov;41(11):1203-12. doi: 10.1136/jcp.41.11.1203.
These guidelines refer to laboratory tests for monitoring changes in acute phase proteins in patients with an inflammatory response to tissue damage. Quantitative measurements of acute phase proteins are a valuable indicator of the presence, extent, and response of inflammation to treatment. When short term (less than 24 hours) changes in the inflammatory response are expected, quantitative assay of C reactive protein is the test of choice. The hyperproteinaemia that develops in response to a longer term (more than 24 hours) inflammatory response is complex and may vary from one disease to another. A test that is sensitive to the combined effect of several plasma proteins is therefore indicated, and appropriate tests include the erythrocyte sedimentation rate and plasma viscosity--the latter having several advantages. Tests for monitoring short term and long term changes in acute phase proteins are complementary and should be used for different clinical purposes; no one test is ideal for all clinical situations. A quality control programme is an essential component of laboratory tests for monitoring the acute phase response.
这些指南涉及用于监测对组织损伤有炎症反应患者急性期蛋白变化的实验室检测。急性期蛋白的定量测量是炎症存在、程度及对治疗反应的一项重要指标。当预期炎症反应在短期内（少于24小时）发生变化时，C反应蛋白定量检测是首选检测方法。对长期（超过24小时）炎症反应产生的高蛋白血症情况较为复杂，且可能因疾病不同而有所差异。因此，需要一种对几种血浆蛋白综合作用敏感的检测方法，合适的检测包括红细胞沉降率和血浆黏度——后者具有多项优势。监测急性期蛋白短期和长期变化的检测方法是互补的，应根据不同临床目的使用；没有一种检测方法适用于所有临床情况。质量控制程序是监测急性期反应实验室检测的重要组成部分。
