Kerouanton Anna, Jimenez Irene, Cellier Cecile, Laurence Valerie, Helfre Sylvie, Pannier Stephanie, Mary Pierre, Freneaux Paul, Orbach Daniel
*Pediatric, Adolescent and Young Adult Department Departments of †Radiology ‡Medical Oncology #Pathology §Radiotherapy Department, Institut Curie ∥Pediatric Orthopedic Department, Necker Hospital-Assistance Publique, Université Paris Descartes-Sorbonne Paris ¶Pediatric Orthopedic Department, Armand Trousseau Hospital-Assistance Publique, Paris, France.
J Pediatr Hematol Oncol. 2014 May;36(4):257-62. doi: 10.1097/MPH.0000000000000154.
Synovial sarcoma (SS) is a high-grade soft tissue sarcoma characterized by local invasiveness and a propensity to metastasize, affecting pediatric, adolescent, and adult populations. The peak incidence is observed in the third decade of life and SS is the most common nonrhabdomyosarcoma soft tissue sarcoma in childhood and adolescence. Although pediatric and adult SS appear clinically and radiologically identical, treatment modalities may differ according to the patient's age. For many years, pediatric oncologists have treated SS as a chemosensitive tumor according to the "rhabdomyosarcoma philosophy." In contrast, adult oncologists generally treat this tumor as a poorly chemosensitive tumor and focus on local control. The authors propose an update of SS in the pediatric population and analyze their results to those obtained in adults.
滑膜肉瘤（SS）是一种高级别软组织肉瘤，其特征为具有局部侵袭性和转移倾向，可影响儿童、青少年及成人。发病高峰出现在生命的第三个十年，并且滑膜肉瘤是儿童和青少年中最常见的非横纹肌肉瘤软组织肉瘤。尽管儿童和成人的滑膜肉瘤在临床和放射学表现上相同，但治疗方式可能因患者年龄而异。多年来，儿科肿瘤学家一直根据“横纹肌肉瘤理念”将滑膜肉瘤视为对化疗敏感的肿瘤。相比之下，成人肿瘤学家通常将这种肿瘤视为化疗敏感性差的肿瘤，并将重点放在局部控制上。作者提出了儿童滑膜肉瘤的最新情况，并将其结果与成人的结果进行分析对比。
