Duke University Medical Center, 3331 DUMC, Durham, NC, 27710, USA.
Curr Cardiol Rep. 2014 May;16(5):477. doi: 10.1007/s11886-014-0477-4.
The clinical significance of persistent patent foramen ovale (PFO) is not well defined. Empirically, PFO has been associated with many clinical conditions. In cryptogenic stroke, migraine, and orthodeoxia/platypnea, a plausible biologic mechanism exists to support PFO closure as a possible treatment. Although transcatheter closure of PFO has been available for over 2 decades, it has remained controversial due to a paucity of evidence to guide patient and device selection. Contemporary studies investigating PFO closure as treatment for patients with these conditions have been published recently and longitudinal data regarding the safety and efficacy of the devices is now available. In this review, we aim to describe the potential clinical significance of a patent foramen in the adult, appraise the newest additions to the body of evidence, and discuss the safety, benefit, patient selection, and future of transcatheter treatment of PFO.
持续性卵圆孔未闭（PFO）的临床意义尚未明确。临床上，PFO 与许多临床病症相关联。在隐源性卒中、偏头痛和体位性低氧/低通气综合征中，存在一种合理的生物学机制来支持 PFO 关闭作为一种可能的治疗方法。尽管经导管 PFO 封堵术已经应用了 20 多年，但由于缺乏指导患者和器械选择的证据，该技术仍然存在争议。最近发表了一些关于 PFO 封堵术治疗这些病症患者的当代研究，关于器械安全性和有效性的纵向数据现在也已经可用。在这篇综述中，我们旨在描述成人中 PFO 的潜在临床意义，评估证据体系中的最新进展，并讨论经导管 PFO 封堵术的安全性、获益、患者选择和未来。
