de Sousa Maria da Glória Teixeira, Belda Walter, Spina Ricardo, Lota Priscila Ramos, Valente Neusa Sakai, Brown Gordon D, Criado Paulo Ricardo, Benard Gil
Laboratory of Medical Investigation Unit 53, Division of Clinical Dermatology Laboratory of Medical Mycology, Tropical Medicine Institute.
Division of Clinical Dermatology, Clinics Hospital, Medical School, University of Sao Paulo, Brazil.
Clin Infect Dis. 2014 Jun;58(12):1734-7. doi: 10.1093/cid/ciu168. Epub 2014 Mar 14.
Chromoblastomycosis is a subcutaneous mycosis that remains a therapeutic challenge, with no standard treatment and high rates of relapse. On the basis of our recent discoveries in mouse models, we tested the efficacy of topical applications of imiquimod to treat patients afflicted with this chronic fungal infection. We report results of treatment for the first 4 recipients of topical imiquimod, all of whom displayed a marked improvement of their lesions, both with and without concurrent oral antifungal therapy.
着色芽生菌病是一种皮下真菌病，仍然是一个治疗难题，没有标准治疗方法且复发率高。基于我们最近在小鼠模型中的发现，我们测试了局部应用咪喹莫特治疗患有这种慢性真菌感染患者的疗效。我们报告了首批4名局部应用咪喹莫特患者的治疗结果，所有患者无论是否同时接受口服抗真菌治疗，其皮损均有显著改善。
