Donazzan Luca, Mahfoud Felix, Linz Dominik, Ewen Sebastian, Ukena Christian, Böhm Michael
Klinik für Innere Medizin III (Kardiologie, Angiologie und Internistische Intensivmedizin), Universitätsklinikum des Saarlandes, Kirrberger Str. 1, Geb. 40, 66421, Homburg, Saar, Germany.
Curr Hypertens Rep. 2014 May;16(5):430. doi: 10.1007/s11906-014-0430-3.
Hypertension has wide (30-45 %) prevalence in the general population and is related to important increases in overall cardiovascular morbidity and mortality. Despite lifestyle modifications and optimal medical therapy (three drugs, one being diuretic), about 5-20 % of hypertensives are affected by resistant hypertension. Chronic high blood pressure has adverse effects on the heart and other organs such as the kidneys and vasculature. Renal sympathetic denervation and baroreceptor stimulation are invasive approaches initially investigated to treat resistant hypertension. Their pleiotropic effects appear promising in cardiovascular remodeling, heart failure and arrhythmias and could potentially affect cardiovascular morbidity and mortality.
高血压在普通人群中的患病率很高（30%-45%），并且与总体心血管发病率和死亡率的显著增加有关。尽管采取了生活方式干预和最佳药物治疗（三种药物，其中一种为利尿剂），仍有5%-20%的高血压患者受难治性高血压影响。慢性高血压会对心脏以及肾脏和血管等其他器官产生不良影响。肾交感神经去神经支配和压力感受器刺激是最初研究用于治疗难治性高血压的侵入性方法。它们的多效性作用在心血管重塑、心力衰竭和心律失常方面似乎很有前景，并且可能会影响心血管发病率和死亡率。
