高血压的病理生理学：马赛克理论及其他。
Pathophysiology of Hypertension: The Mosaic Theory and Beyond.
机构信息
Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (D.G.H.).
Cardiovascular and Metabolic Disorders Research Program, Duke-National University of Singapore Medical School, Singapore (T.M.C.).
出版信息
Circ Res. 2021 Apr 2;128(7):847-863. doi: 10.1161/CIRCRESAHA.121.318082. Epub 2021 Apr 1.
Abstract
Dr Irvine Page proposed the Mosaic Theory of Hypertension in the 1940s advocating that hypertension is the result of many factors that interact to raise blood pressure and cause end-organ damage. Over the years, Dr Page modified his paradigm, and new concepts regarding oxidative stress, inflammation, genetics, sodium homeostasis, and the microbiome have arisen that allow further refinements of the Mosaic Theory. A constant feature of this approach to understanding hypertension is that the various nodes are interdependent and that these almost certainly vary between experimental models and between individuals with hypertension. This review discusses these new concepts and provides an introduction to other reviews in this compendium of .
摘要
欧文·佩奇博士在 20 世纪 40 年代提出了高血压的马赛克理论，主张高血压是多种因素相互作用导致血压升高并导致靶器官损伤的结果。多年来，佩奇博士对其范式进行了修正，关于氧化应激、炎症、遗传学、钠稳态和微生物组的新概念相继出现，从而进一步完善了马赛克理论。这种理解高血压的方法的一个不变特征是，各个节点是相互依存的，而且这些节点在实验模型之间以及高血压患者之间几乎肯定是不同的。本文讨论了这些新概念，并对本综述集中的其他综述进行了介绍。
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