CrossTalk opposing view: The pre-Botzinger complex is not essential for respiratory depression following systemic administration of opioid analgesics.
作者信息
Lalley Peter M, Pilowsky Paul M, Forster Hubert V, Zuperku Edward J
出版信息
J Physiol. 2014 Mar 15;592(6):1163-6. doi: 10.1113/jphysiol.2013.258830.
Abstract
摘要
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1
CrossTalk opposing view: The pre-Botzinger complex is not essential for respiratory depression following systemic administration of opioid analgesics.相互矛盾的观点：前包钦格复合体对于全身性给予阿片类镇痛药后的呼吸抑制并非必不可少。
J Physiol. 2014 Mar 15;592(6):1163-6. doi: 10.1113/jphysiol.2013.258830.
2
CrossTalk proposal: The preBotzinger complex is essential for the respiratory depression following systemic administration of opioid analgesics.串扰假说：前包钦格复合体对于全身性给予阿片类镇痛药后的呼吸抑制至关重要。
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Activation of μ-opioid receptors differentially affects the preBötzinger Complex and neighbouring regions of the respiratory network in the adult rabbit.μ 阿片受体的激活对成年兔的 PreBötzinger 复合体和呼吸网络的邻近区域有不同的影响。
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Mu-opioid receptor agonist effects on medullary respiratory neurons in the cat: evidence for involvement in certain types of ventilatory disturbances.μ-阿片受体激动剂对猫延髓呼吸神经元的作用：参与某些类型通气障碍的证据
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Clinically relevant infusion rates of mu-opioid agonist remifentanil cause bradypnea in decerebrate dogs but not via direct effects in the pre-Bötzinger complex region.临床相关输注率的μ-阿片受体激动剂瑞芬太尼引起去大脑狗的呼吸过缓，但不是通过在 Pre-Bötzinger 复合体区域的直接作用。
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Respiratory function in adult mice lacking the mu-opioid receptor: role of delta-receptors.缺乏μ-阿片受体的成年小鼠的呼吸功能：δ-受体的作用
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Micro-opioid receptor agonist injections into the presumed pre-Botzinger complex and the surrounding region of awake goats do not alter eupneic breathing.在清醒的山羊中，向假定的前包钦格复合体及其周围区域注射 μ 阿片受体激动剂不会改变生理性呼吸。
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Morphine-induced acetylcholine release at the hypoglossal motor nucleus: implications for opiate-induced respiratory suppression.吗啡诱导舌下运动核乙酰胆碱释放：对阿片类药物诱导的呼吸抑制的影响。
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Current research in pathophysiology of opioid-induced respiratory depression, neonatal opioid withdrawal syndrome, and neonatal antidepressant exposure syndrome.阿片类药物所致呼吸抑制、新生儿阿片类药物戒断综合征及新生儿抗抑郁药暴露综合征的病理生理学研究现状。
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Pontine μ-opioid receptors mediate bradypnea caused by intravenous remifentanil infusions at clinically relevant concentrations in dogs.桥脑 μ 阿片受体介导临床相关浓度瑞芬太尼静脉输注引起犬呼吸过缓。
J Neurophysiol. 2012 Nov;108(9):2430-41. doi: 10.1152/jn.00185.2012. Epub 2012 Aug 8.
2
Opioid μ-receptors in the rostral medullary raphe modulate hypoxia-induced hyperpnea in unanesthetized rats.延髓头端中缝核的阿片μ受体调节未麻醉大鼠缺氧性通气过度。
Acta Physiol (Oxf). 2012 Mar;204(3):435-42. doi: 10.1111/j.1748-1716.2011.02345.x. Epub 2011 Oct 17.
3
Activation of opioid μ-receptors in the commissural subdivision of the nucleus tractus solitarius abolishes the ventilatory response to hypoxia in anesthetized rats.孤束核连合亚核区 μ 阿片受体的激活可消除麻醉大鼠缺氧通气反应。
Anesthesiology. 2011 Aug;115(2):353-63. doi: 10.1097/ALN.0b013e318224cc1f.
4
PreBotzinger complex neurokinin-1 receptor-expressing neurons mediate opioid-induced respiratory depression.PreBotzinger 复合体神经激肽-1 受体表达神经元介导阿片类药物引起的呼吸抑制。
J Neurosci. 2011 Jan 26;31(4):1292-301. doi: 10.1523/JNEUROSCI.4611-10.2011.
5
Clinically relevant infusion rates of mu-opioid agonist remifentanil cause bradypnea in decerebrate dogs but not via direct effects in the pre-Bötzinger complex region.临床相关输注率的μ-阿片受体激动剂瑞芬太尼引起去大脑狗的呼吸过缓，但不是通过在 Pre-Bötzinger 复合体区域的直接作用。
J Neurophysiol. 2010 Jan;103(1):409-18. doi: 10.1152/jn.00188.2009. Epub 2009 Nov 11.
6
Micro-opioid receptor agonist injections into the presumed pre-Botzinger complex and the surrounding region of awake goats do not alter eupneic breathing.在清醒的山羊中，向假定的前包钦格复合体及其周围区域注射 μ 阿片受体激动剂不会改变生理性呼吸。
J Appl Physiol (1985). 2009 Nov;107(5):1591-9. doi: 10.1152/japplphysiol.90548.2008. Epub 2009 Sep 10.
7
Opioid mu-receptors in medullary raphe region affect the hypoxic ventilation in anesthetized rats.延髓中缝区域的阿片类μ受体影响麻醉大鼠的低氧通气。
Respir Physiol Neurobiol. 2009 Sep 30;168(3):281-8. doi: 10.1016/j.resp.2009.07.015. Epub 2009 Jul 24.
8
Opioid receptors on bulbospinal respiratory neurons are not activated during neuronal depression by clinically relevant opioid concentrations.在临床上相关的阿片类药物浓度导致神经元抑制期间，延髓脊髓呼吸神经元上的阿片受体未被激活。
J Neurophysiol. 2008 Nov;100(5):2878-88. doi: 10.1152/jn.90620.2008. Epub 2008 Sep 24.
9
Opioids and the control of respiration.阿片类药物与呼吸控制
Br J Anaesth. 2008 Jun;100(6):747-58. doi: 10.1093/bja/aen094. Epub 2008 May 1.
10
Opioidergic and dopaminergic modulation of respiration.阿片能和多巴胺能对呼吸的调节
Respir Physiol Neurobiol. 2008 Dec 10;164(1-2):160-7. doi: 10.1016/j.resp.2008.02.004.
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