Park Jisoo, Kim Jin-Man, Park Jeong Kyu, Huang Songmei, Kwak Seo Young, Ryu Kyeung A, Kong Gyeyeong, Park Jongsun, Koo Bon Seok
Department of Pharmacology, Metabolic Diseases and Cell Signaling Laboratory, Research Institute for Medical Sciences, Daejeon, South Korea.
Department of Pathology, Metabolic Diseases and Cell Signaling Laboratory, Research Institute for Medical Sciences, Daejeon, South Korea.
Head Neck. 2015 Jul;37(7):953-63. doi: 10.1002/hed.23695. Epub 2014 Jun 27.
This study investigated the role of p21-activated kinase (PAK)-1 in progression of head and neck squamous cell carcinoma (HNSCC).
We examined PAK isoforms and explored whether PAK activation enhanced in vitro invasion of the HNSCC cell line. We analyzed the relationship between PAK1 expression and various clinicopathological features and investigated the effect of PAK1 overexpression on survival in 119 patients with HNSCC.
PAK1 and PAK2 are predominantly expressed in HNSCC cells and patient tissues. Particularly, PAK1 makes the dominant contribution to increase in cell migration and invasion. There was a statistically significant correlation between PAK1 overexpression and aggressive cancer behavior. Moreover, PAK1 seemed to be a prognostic factor for overall and disease-specific survival in patients. Interestingly, enhancement of PAK1 expression was found in the invasive front of cancer.
PAK1 is associated with the aggressive tumor behavior and poor prognosis of head and neck cancer.
本研究调查了p21激活激酶（PAK）-1在头颈部鳞状细胞癌（HNSCC）进展中的作用。
我们检测了PAK亚型，并探讨PAK激活是否增强HNSCC细胞系的体外侵袭能力。我们分析了PAK1表达与各种临床病理特征之间的关系，并研究了PAK1过表达对119例HNSCC患者生存的影响。
PAK1和PAK2主要在HNSCC细胞和患者组织中表达。特别是，PAK1对细胞迁移和侵袭的增加起主要作用。PAK1过表达与侵袭性癌症行为之间存在统计学上的显著相关性。此外，PAK1似乎是患者总生存和疾病特异性生存的一个预后因素。有趣的是，在癌的浸润前沿发现PAK1表达增强。
PAK1与头颈部癌的侵袭性肿瘤行为和不良预后相关。
