Kurtoglu Emel, Kokcu Arif, Celik Handan, Tosun Migraci, Malatyalioglu Erdal
Department of Obstetrics and Gynecology, School of Medicine , University of Ondokuz Mayis, Samsun , Turkey.
J Matern Fetal Neonatal Med. 2015 Jan;28(1):97-9. doi: 10.3109/14767058.2014.905910. Epub 2014 Apr 9.
The aim of the study was to evaluate the relationship between neutrophil to lymphocyte ratio (NLR) and preeclampsia.
Demographic data and laboratory tests for NLR of 203 pregnant women (73 normotensive pregnants, 23 pregnants with mild preeclampsia and 107 pregnants with severe preeclampsia) were retrospectively analyzed. Neutrophil to lymphocyte ratios were compared between the study groups.
Preeclamptic pregnant women had smaller gestation weeks, lower hemoglobin level and fetal birth weight than that of normal pregnant women. NLR in preeclamptic group was significantly higher than that of normal group (p=0.023) and area under ROC curve was found statistically significant (p=0.023). However, there was no statistically significant relationship between NLR and severity, proteinuria level, subjective symptoms and onset time of the disease.
The findings showed that the measurement of NLR periodically may be useful to predict high-risk pregnancies in terms of preeclampsia, but further studies are needed to determine its contribution.
本研究旨在评估中性粒细胞与淋巴细胞比值（NLR）与子痫前期之间的关系。
回顾性分析203名孕妇（73名血压正常的孕妇、23名单纯性轻度子痫前期孕妇和107名重度子痫前期孕妇）的人口统计学数据及NLR的实验室检查结果。比较各研究组之间的中性粒细胞与淋巴细胞比值。
子痫前期孕妇的孕周、血红蛋白水平和胎儿出生体重均低于正常孕妇。子痫前期组的NLR显著高于正常组（p=0.023），且ROC曲线下面积具有统计学意义（p=0.023）。然而，NLR与疾病的严重程度、蛋白尿水平、主观症状及发病时间之间无统计学意义的相关性。
研究结果表明，定期检测NLR对于预测子痫前期的高危妊娠可能有用，但仍需进一步研究以确定其作用。
